Last update Oct. 25, 2023

アルカフタジン

Compatible

Safe product and/or breastfeeding is the best option.

Alcaftadine is a histamine H1-receptor antagonist for ophthalmic use to prevent itching associated with allergic conjunctivitis in adults and children from 2 years of age. Topical administration once daily as eye drops.

At the time of the last update, we found no published data on its excretion in breast milk.

It reaches peak plasma concentrations of less than 120 pg/ml (Bohets 2011, Allergan 2011), so passage into milk must be negligible.

The small dose and low plasma absorption of most topical ophthalmic preparations make passage of significant amounts into breast milk unlikely.

For ophthalmic administration, absorption can be minimised by pressing the tear duct (inner canthus of the eye) with the finger for 1-2 minutes and administering the dose immediately after breastfeeding. (Belkin 2020, Blumen 2020)

Alternatives

We do not have alternatives for アルカフタジン since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

アルカフタジン is Alcaftadine in Japanese.

Is written in other languages:

Group

アルカフタジン belongs to this group or family:

Tradenames

Main tradenames from several countries containing アルカフタジン in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 307 daltons
Protein Binding 39 - 63 %
Tmax 0.25 hours
2 hours
Theoretical Dose < 0.00001 mg/Kg/d

References

  1. Belkin A, Chen T, DeOliveria AR, Johnson SM, Ramulu PY, Buys YM; American Glaucoma Society and the Canadian Glaucoma Society.. A Practical Guide to the Pregnant and Breastfeeding Patient with Glaucoma. Ophthalmol Glaucoma. 2020 Mar - Apr;3(2):79-89. Abstract
  2. Blumen-Ohana E, Sellem E. [Pregnancy & glaucoma: SFO-SFG recommendations]. J Fr Ophtalmol. 2020 Jan;43(1):63-66. Abstract
  3. Alcaftadina. Ficha técnica. 2011 Full text (in our servers)
  4. Alcaftadine. Data Sheet. 2011 Full text (in our servers)
  5. Bohets H, McGowan C, Mannens G, Schroeder N, Edwards-Swanson K, Shapiro A. Clinical pharmacology of alcaftadine, a novel antihistamine for the prevention of allergic conjunctivitis. J Ocul Pharmacol Ther. 2011 Abstract

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