Last update Jan. 18, 2023

氨苯蝶啶 

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a potassium-sparing diuretic with actions and uses similar to those of amiloride used in the treatment of edema and in the management of hypertension. It is usually associated with hydrochlorothiazide or furosemide. Oral administration once or twice a day.

At the date of the last update we did not find any published data on its excretion in breast milk.

Long-term treatment with diuretic drugs may compromise the state of hydration of the nursing mother. Must make an adjustment (decrease) of the dose based on the estimated milk production and monitor milk production. Use a lower dose as possible, especially during the first postnatal month.

Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

氨苯蝶啶  is Triamterene in Chinese.

Is written in other languages:

Group

氨苯蝶啶  belongs to this group or family:

Tradenames

Main tradenames from several countries containing 氨苯蝶啶  in its composition:

  • Apo-Triazide™. Contains other elements than 氨苯蝶啶  in its composition
  • Drinamil™. Contains other elements than 氨苯蝶啶  in its composition
  • Dyazide™. Contains other elements than 氨苯蝶啶  in its composition
  • Dyrenium
  • Dytide H™. Contains other elements than 氨苯蝶啶  in its composition
  • Fluss™. Contains other elements than 氨苯蝶啶  in its composition
  • Frusene™. Contains other elements than 氨苯蝶啶  in its composition
  • Furesis comp™. Contains other elements than 氨苯蝶啶  in its composition
  • Hidroronol T™. Contains other elements than 氨苯蝶啶  in its composition
  • Hydrene™. Contains other elements than 氨苯蝶啶  in its composition
  • Iguassina™. Contains other elements than 氨苯蝶啶  in its composition
  • Maxzide™. Contains other elements than 氨苯蝶啶  in its composition
  • Nephral™. Contains other elements than 氨苯蝶啶  in its composition
  • Prestole™. Contains other elements than 氨苯蝶啶  in its composition
  • Propra comp™. Contains other elements than 氨苯蝶啶  in its composition
  • Salidur™. Contains other elements than 氨苯蝶啶  in its composition
  • Triamco™. Contains other elements than 氨苯蝶啶  in its composition
  • Triampur Compositum (Триампур Композитум)™. Contains other elements than 氨苯蝶啶  in its composition
  • Triampur compositum™. Contains other elements than 氨苯蝶啶  in its composition
  • Turfa™. Contains other elements than 氨苯蝶啶  in its composition
  • Uren™. Contains other elements than 氨苯蝶啶  in its composition

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 52 - 67 %
Molecular weight 253 daltons
Protein Binding 67 %
VD 1.49 l/Kg
pKa 15.88 -
Tmax 1.1 - 2 hours
1.5 - 2 hours

References

  1. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source)
  2. Pro Doc Ltée. Triamterene&Hydrochlorothiazide. Drug Summary. 2014 Full text (in our servers)

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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America

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