Last update Jan. 16, 2023
Very Low Risk
We do not have alternatives for Spironolactone since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Spironolactone is also known as
Spironolactone belongs to this group or family:
Main tradenames from several countries containing Spironolactone in its composition:
|Tmax||1 - 2.6||hours|
|T½||13 - 24||hours|
|M/P ratio||0.5 - 0.7||-|
|Ped.Relat.Dose||0.5 - 1.6||%|
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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana of Spain
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
It is a steroid with a structure similar to that of the natural adrenocortical hormone aldosterone, being an antagonist of aldosterone receptors. It acts as a potassium-sparing diuretic, increasing the excretion of sodium and water. It is used for the treatment of hypertension, primary hyperaldosteronism, edema due to heart failure, liver cirrhosis, nephrotic syndrome, or associated with malignancy, and hypokalemia. It has antiandrogenic properties and is used to treat hirsutism, particularly polycystic ovarian syndrome. It is a prodrug that is metabolized to canrenone. Oral administration once a day
Excretion into breast milk is clinically non-significant (Phelps 1977) and without side-effects observed in breastfed infants of treated mothers. (de Jong 2022, Reisman 2018, Gutgesell 1990, Phelps 1977)
A medication which is used for treatment of infants even in the neonatal period.
It decreases slightly the secretion of Prolactin, however, instead other diuretic drugs, a suppressive effect on lactation has not been reported.
It can cause gynecomastia. (Trinchieri 2021, Deepinder 2012, Cuculi 2007)
American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001). Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs: compatible with Breastfeeding. (WHO 2002)