Last update June 18, 2022
Tricyclic antidepressant derived from loxapine with properties similar to amitriptyline. Inhibits dopamine reuptake. Two to three times daily oral administration.
It is excreted in human milk in a clinically non-significant amount. (Gelenberg 1979)
It can cause hyperprolactinemia and galactorrhea. (Egberts 1997, Koizumi 1986, Robertson 1982, Cooper 1981, Gelenberg 1979, Jaffe 1978)
As there is less published experience than with other antidepressant drugs (Rubin 2004), known safer alternatives may be preferable (Sriraman 2015, Davanzo 2011, ABM 2008), especially during the neonatal period and in case of prematurity.
Women suffering from depression during pregnancy need more breastfeeding support due to their increased risk of breastfeeding problems and early weaning. (Grzeskowiak 2018, Leggett 2017, Venkatesh 2017, Gorman 2012)
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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