Last update Sept. 5, 2022

Amantadine Hydrochloride

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

It is a dopamine agonist that is used as an antiparkinsonian. It also has antiviral properties and is used in the treatment and prophylaxis of influenza type A and herpes zoster. Oral administration.

At latest update relevant published data on excretion into breast milk were not found. Because of large volume of distribution and low plasma level observed (Pacifici 1976), a passage of significant amount through breastmilk or side-effects on the infant are not likely to occur.

Amantadine reduces plasma levels of prolactin, it has been used to treat galactorrhea caused by the use of dopaminergic neuroleptic drugs (Siever 1981 Correa 1987, Marken 1992, Carvalho 2011), however there is not information about the effect on lactating mothers. Prolactin is important to milk production especially during the first few weeks within birth. Frequent and effective stimulation of the nipple by the infant is essential on the maintenance of breastfeeding.

Whether administered during breastfeeding, it would be advisable not to use it in the neonatal period and monitor milk production.


Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Amantadine Hydrochloride is also known as

Amantadine Hydrochloride in other languages or writings:


Amantadine Hydrochloride belongs to these groups or families:


Main tradenames from several countries containing Amantadine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. 86 - 90 %
Molecular weight 188 daltons
Protein Binding 67 %
VD 4.2 (3 - 8) l/Kg
Tmax 1 - 4 hours
10 - 15 hours


  1. Novartis. Amantadine. Data Sheet. 2011 Full text (in our servers)
  2. Carvalho MM, Góis C. [Hyperprolactinemia in mentally ill patients]. Acta Med Port. 2011 Abstract
  3. AEMPS. Amantadina. Ficha técnica. 2010 Full text (in our servers)
  4. Marken PA, Haykal RF, Fisher JN. Management of psychotropic-induced hyperprolactinemia. Clin Pharm. 1992 Abstract
  5. Correa N, Opler LA, Kay SR, Birmaher B. Amantadine in the treatment of neuroendocrine side effects of neuroleptics. J Clin Psychopharmacol. 1987 Abstract
  6. Siever LJ. The effect of amantadine on prolactin levels and galactorrhea on neuroleptic-treated patients. J Clin Psychopharmacol. 1981 Abstract
  7. Pacifici GM, Nardini M, Ferrari P, Latini R, Fieschi C, Morselli PL. Effect of amantadine on drug-induced parkisonism: relationship between plasma levels and effect. Br J Clin Pharmacol. 1976 Abstract

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