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Aminocaproic acid is an amino acid, similar to lysine and arginine, with antifibrinolytic properties used in the treatment and prophylaxis of bleeding associated with excessive fibrinolysis. It has been used in the prophylaxis of hereditary angioedema, to induce postoperative coagulation and, together with factor VIII or IX, in hemophilia. Oral or intravenous administration.
At the time of the last update, we found no published data on its excretion in breast milk.
Its high volume of distribution makes it difficult to pass into breast milk.
To minimize the possible exposure of the drug through breast milk, it is advisable to wait 3 to 5 T1/2 (6 to 10 hours) after the last dose before resuming breastfeeding. This is not necessary if the drug has been administered at delivery or in the immediate postpartum period, since the small amount of colostrum that the newborn takes in does not contain a significant amount of the drug.
Expert authors consider safer alternatives known to be preferable during lactation (Yeich 2023, Évora 2021, Hawke 2016), especially during the neonatal period and in case of prematurity.