Last update Oct. 25, 2023
Compatible
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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Alfentanil Hydrochloride in other languages or writings:
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e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2015 of United States of America
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It is a short-acting opioid analgesic related to fentanyl. It is used to induce and maintain anaesthesia and as an analgesic and respiratory depressant in the treatment of mechanically ventilated patients. Intravenous administration.
It is excreted in breast milk (colostrum) in negligible amount. (Giesecke 1985)
Its pharmacokinetic data (large volume of distribution and high percentage of plasma protein binding) make passage into breast milk unlikely in clinically significant amounts.
Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk.
Expert authors consider this medication safe for use during breastfeeding. (Hale, LactMed, Briggs 2015, Spigset 1994, Lee 1993)
As there is little published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.