Last update Oct. 25, 2023

Alfentanil Hydrochloride

Compatible

Safe product and/or breastfeeding is the best option.

It is a short-acting opioid analgesic related to fentanyl. It is used to induce and maintain anaesthesia and as an analgesic and respiratory depressant in the treatment of mechanically ventilated patients. Intravenous administration.

It is excreted in breast milk (colostrum) in negligible amount. (Giesecke 1985)

Its pharmacokinetic data (large volume of distribution and high percentage of plasma protein binding) make passage into breast milk unlikely in clinically significant amounts.

Its low oral bioavailability makes it difficult to pass into infant plasma from ingested breast milk.

Expert authors consider this medication safe for use during breastfeeding. (Hale, LactMed, Briggs 2015, Spigset 1994, Lee 1993)

As there is little published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Alternatives

  • Fentanyl (Safe product and/or breastfeeding is the best option.)
  • Ibuprofen (Safe product and/or breastfeeding is the best option.)
  • Paracetamol (Safe product and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Alfentanil Hydrochloride in other languages or writings:

Group

Alfentanil Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Alfentanil Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 43 %
Molecular weight 453 daltons
Protein Binding 92 %
VD 0.4 - 1 l/Kg
Tmax 0.1 hours
1.5 - 2 hours
Theoretical Dose 0.0001 (0.00003 - 0.0002) mg/Kg/d
Relative Dose 0.3 - 0.4 %
Ped.Relat.Dose 0. 1 - 0.5 %

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  4. Spigset O. Anaesthetic agents and excretion in breast milk. Acta Anaesthesiol Scand. 1994 Abstract
  5. Lee JJ, Rubin AP. Breast feeding and anaesthesia. Anaesthesia. 1993 Jul;48(7):616-25. Review. Abstract Full text (link to original source) Full text (in our servers)
  6. Giesecke AH, Rice LJ, Lipton JM. Alfentanil in colostrum. Anesthesiology. 63:A284. 1985

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