Last update July 2, 2025

Aesculin, Esculin

Compatible

Safe product and/or breastfeeding is the best option.

Product related to hydroxycoumarin, present in the bark of the horse chestnut tree, used as an anti-varicose, vasoprotective, anti-haemorrhagic and anti-haemorrhoidal agent. Oral, intravenous and rectal administration.

At the date of the last update, we found no published data on its excretion in breast milk.

It has very low intestinal absorption. (Martindale)

Do not apply to the breast or clean thoroughly before breastfeeding.

Given its lack of toxicity at usual doses, moderate consumption during breastfeeding would be very low risk.


See below the information of these related products:

  • Dicumarol (Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.)
  • Horse Chestnut (Safe product and/or breastfeeding is the best option.)

Alternatives

We do not have alternatives for Aesculin, Esculin since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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José María Paricio, founder of e-lactancia.
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Other names

Aesculin, Esculin is also known as


Aesculin, Esculin in other languages or writings:

  • C15H16O9 (Molecular formula)

Group

Aesculin, Esculin belongs to this group or family:

Tradenames

Main tradenames from several countries containing Aesculin, Esculin in its composition:

List of 27 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 340 daltons
pKa 8.12 -
Tmax 1 hours
T½ 20 hours

References

  1. Zając M, Wiśniewski M, Sein Anand J. [Intoxication by powdered seeds of horse chestnut (Aesculus hippocastanum) used nasally as snuff - a case report]. Przegl Lek. 2014 Abstract
  2. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2012 Abstract Full text (link to original source)
  3. Methlie CB, Schjøtt J. [Horse chestnut--remedy for chronic venous insufficiency]. Tidsskr Nor Laegeforen. 2009 Abstract
  4. Pittler MH, Ernst E. Horse chestnut seed extract for chronic venous insufficiency. Cochrane Database Syst Rev. 2004 Abstract
  5. Siebert U, Brach M, Sroczynski G, Berla K. Efficacy, routine effectiveness, and safety of horsechestnut seed extract in the treatment of chronic venous insufficiency. A meta-analysis of randomized controlled trials and large observational studies. Int Angiol. 2002 Abstract

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