Last update Oct. 26, 2023

Adenosine Monophosphate (AMP

Very Low Risk

Safe. Compatible. Minimal risk for breastfeeding and infant.

Adenosine monophosphate (AMP) is an endogenous adenine nucleotide, found in the body and in many foods of animal (meat) and plant (seeds) origin. Like adenosine, it occurs naturally in the body and is linked to the metabolism of ATP or adenosine triphosphate. It is involved in many biological processes.  Nucleotides are used in food as a supplement, additive and flavouring that reduces the bitter taste of food. Nucleotides are found in breast milk and are added to breast-milk substitute formulas  (Yang 2022, Green 2016, Pickering 1998). AMP is claimed to have vasodilatory properties and has been used, without evidence of efficacy, in venous insufficiency, haemorrhoids and varicose veins as well as in pain and inflammation. 

At the time of the last update, we have found no published data on its excretion in breast milk.

Due to its protein nature, it is inactivated in the gastrointestinal tract and is not absorbed (oral bioavailability practically nil), which makes it difficult or impossible for it to pass into infant plasma from ingested breast milk.

Product with very few bibliographical references and/or very old, marketed in few countries.

Although they are devoid of toxicity and many European agencies do not consider a maximum amount of exogenous intake of nucleotides, the Spanish Agency for Food Safety and Nutrition proposes a maximum daily intake of 0.45 g (7.5 mg/kg of body weight) as the sum total of Adenosine, Cytidine, Guanosine, Inosine and Uridine. (AESAN 2012)

Alternatives

We do not have alternatives for Adenosine Monophosphate (AMP since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Adenosine Monophosphate (AMP is also known as


Adenosine Monophosphate (AMP in other languages or writings:

Tradenames

Main tradenames from several countries containing Adenosine Monophosphate (AMP in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ≈ 0 %
Molecular weight 347 daltons

References

  1. Yang L, Guo Z, Yu M, Cai X, Mao Y, Tian F, Xu W, Liu G, Li X, Zhao Y, Xie L. Profile of Nucleotides in Chinese Mature Breast Milk from Six Regions. Nutrients. 2022 Mar 29;14(7). pii: 1418. Abstract Full text (link to original source)
  2. Green Corkins K, Shurley T. What's in the Bottle? A Review of Infant Formulas. Nutr Clin Pract. 2016 Dec;31(6):723-729. Abstract
  3. AESAN. Informe del Comité Científico de la Agencia Española de Seguridad Alimentaria y Nutrición (AESAN) sobre condiciones de uso de determinadas sustancias distintas de vitaminas, minerales y plantas para ser empleadas en complementos alimenticios - 1. Revista del comité científico nº 17. 2012 Full text (in our servers)
  4. Pickering LK, Granoff DM, Erickson JR, Masor ML, Cordle CT, Schaller JP, Winship TR, Paule CL, Hilty MD. Modulation of the immune system by human milk and infant formula containing nucleotides. Pediatrics. 1998 Feb;101(2):242-9. Abstract

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