Last update Nov. 10, 2022

Ademetionine; Ademethionine

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

A molecule that is synthesized by joining Methionine to Adenosine which is naturally widely present in human body. Without any clear scientific base it is used for liver disorders, depression and osteoarthritis (Sharma 2017). It is a product with low therapeutic effectiveness. (INSALUD 2001). It comes from the liver metabolization of methionine. Oral and parenteral administration.

Since the last update we have not found published data on its excretion in breastmilk.

Its very low oral bioavailability minimizes the passage into plasma of the infant from ingested breast milk, except in the premature and in the immediate neonatal period in which there may be greater intestinal permeability.

It is a product with few and not serious side effects, although at high doses they can cause psychiatric symptoms in vulnerable people. (Goren 2004)

Expert authors consider the use of this medication possible during breastfeeding. (LactMed, Hale)

 

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Other names

Ademetionine; Ademethionine is also known as


Ademetionine; Ademethionine in other languages or writings:

Groups

Ademetionine; Ademethionine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Ademetionine; Ademethionine in its composition:

List of 11 tradenames

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Baja - Low %
Molecular weight 398 daltons
Protein Binding 10 %
VD 0.4 l/Kg
T½ 1.2 hours

References

  1. LactMed. Drugs and Lactation Database (LactMed). Internet. Bethesda (MD): National Library of Medicine (US); 2006-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK501922/ 2006 - Consulted on April 16, 2024 Full text (link to original source)
  2. Hale TW. Medications & Mothers' Milk. 1991- . Springer Publishing Company. Available from https://www.halesmeds.com Consulted on April 10, 2024 Full text (link to original source)
  3. Sharma A, Gerbarg P, Bottiglieri T, Massoumi L, Carpenter LL, Lavretsky H, Muskin PR, Brown RP, Mischoulon D; as Work Group of the American Psychiatric Association Council on Research.. S-Adenosylmethionine (SAMe) for Neuropsychiatric Disorders: A Clinician-Oriented Review of Research. J Clin Psychiatry. 2017 Jun;78(6):e656-e667. Abstract
  4. Gören JL, Stoll AL, Damico KE, Sarmiento IA, Cohen BM. Bioavailability and lack of toxicity of S-adenosyl-L-methionine (SAMe) in humans. Pharmacotherapy. 2004 Nov;24(11):1501-7. Abstract
  5. INSALUD. Área de Gestión de Farmacia. Subdirección General de Atención Primaria. Instituto Nacional de la Salud. Utilidad terapéutica de los medicamentos financiados por el Sistema Nacional de Salud. . 2001 Full text (in our servers)

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