Last update Feb. 7, 2022

A mixture of theophylline and ethylenediamine (2:1)

Compatible

Safe substance and/or breastfeeding is the best option.

Aminophylline is a combination of theophylline and ethylenediamine in a 2:1 ratio. Once in the body, theophylline is released and performs its bronchodilator action. Intravenous or oral administration in two daily doses.

Theophylline is excreted in human milk in small amounts but it could be clinically significant (Gardner 1987, Reinhardt 1983, Stec 1980, Yurchak 1976).
Except in the case of a newborn who developed irritability and difficulties falling asleep, no problems have been observed in infants whose mothers mothers treated with theophylline (Yurchak 1976). 

Maternal theophylline serum levels must be monitored and maintained at 5 - 12 mcg / mL (National Asthma 2004). 

Several medical societies, experts and expert consensus, consider the use of this medication to be compatible during breastfeeding. ((Middleton 2020, National Asthma Ed. 2004)

American Academy of Pediatrics: theophylline is usually compatible with breastfeeding (AAP 2001).
List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).

Monitor the appearance of irritability or insomnia in the infant.

Known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.


See below the information of this related product:

  • Theophylline (Safe substance and/or breastfeeding is the best option.)

Alternatives

  • Albuterol (Safe substance and/or breastfeeding is the best option.)
  • Terbutaline Sulfate (Safe substance and/or breastfeeding is the best option.)

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

A mixture of theophylline and ethylenediamine (2:1) is Aminophylline in Chemical name.

Is written in other languages:

A mixture of theophylline and ethylenediamine (2:1) is also known as

Group

A mixture of theophylline and ethylenediamine (2:1) belongs to this group or family:

Tradenames

Main tradenames from several countries containing A mixture of theophylline and ethylenediamine (2:1) in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 420 daltons
Protein Binding 40 - 65 %
VD 0.45 (0.3 - 0.7) l/Kg
pKa 7.82 -
Tmax 4 hours
7 - 9 hours
M/P ratio 0.5 - 1.1 -
Theoretical Dose 0.4 - 1 mg/Kg/d
Relative Dose 5 - 11 %
Ped.Relat.Dose 3.5 - 8.3 %

References

  1. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  2. National Asthma Education and Prevention Program Asthma and Pregnancy Working Group. Managing asthma during pregnancy: recommendations for pharmacologic treatment-2004 update. 2004;1-57. None 2004 Full text (link to original source) Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Abstract Full text (link to original source) Full text (in our servers)
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Gardner MJ, Schatz M, Cousins L, Zeiger R, Middleton E, Jusko WJ. Longitudinal effects of pregnancy on the pharmacokinetics of theophylline. Eur J Clin Pharmacol. 1987;32(3):289-95. Abstract
  6. Reinhardt D, Richter O, Brandenburg G. [Pharmacokinetics of drugs from the breast-feeding mother passing into the body of the infant, using theophylline as an example]. Monatsschr Kinderheilkd. 1983 Feb;131(2):66-70. German. Abstract
  7. Stec GP, Greenberger P, Ruo TI, Henthorn T, Morita Y, Atkinson AJ Jr, Patterson R. Kinetics of theophylline transfer to breast milk. Clin Pharmacol Ther. 1980 Sep;28(3):404-8. Abstract
  8. Yurchak AM, Jusko WJ. Theophylline secretion into breast milk. Pediatrics. 1976 Apr;57(4):518-20. Abstract

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