Last update Feb. 7, 2022
Very Low Risk
Theophylline is a xanthine derivative chemically similar to caffeine and theobromine. It is used to treat asthma and bronchospasm. It is used as treatment of apnea on premature babies. Oral and intravenous administration every 6 to 8 hours.
It is excreted in human milk in small amounts but it could be clinically significant (Gardner 1987, Reinhardt 1983, Stec 1980, Yurchak 1976).
Except in the case of a newborn who developed irritability and difficulties falling asleep, no problems have been observed in infants whose mothers took it (Yurchak 1976).
Maternal serum levels must be monitored and maintained at 5 - 12 mcg / mL (National Asthma 2004).
Several medical societies, experts and expert consensus, consider the use of this medication to be compatible during breastfeeding. (Middleton 2020, National Asthma Ed. 2004)
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
List of WHO essential medicines: compatible with breastfeeding (WHO / UNICEF 2002).
Monitor the appearance of irritability or insomnia in the infant.
Known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Academy of Breastfeeding Medicine - 2012 of United States of America
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM