4-Carboxyl-4-(N-phenylpropionamido)-1-piperidine propionic acid dimethyl ester monohydrate

Opioid analgesic related to fentanyl used in the induction and maintenance of general anesthesia, in postoperative analgesia and in local or regional anesthesia. intravenous administration.

Since the last update we have not found published data on its excretion in breastmilk.

Although its pharmacokinetic data (low molecular weight, low protein binding, high lipid solubility and low volume of distribution) make easy the passage into breast milk, its very short half-life (less than 10 minutes) makes its excretion in breast milk unlikely.  

No problems have been observed in breastfed infants aged 3 to 5 months whose mothers received remifentanil, propofol, rocuronium, and xenon for anesthesia for surgical procedures. ^{(Stuttman 2010)}

There were no significant differences in breastfeeding initiation, continuation, or problems between the groups of mothers treated with pethidine, meperidine, or remifentanil. ^{(Moran 2019, Evron 2005)}

The mother may breastfeed the baby as soon as she is recovered from anesthesia. No need to express and discard breast milk. ^{(Reece 2017)}

 

Expert authors consider the use of this medication to be probably safe during breastfeeding. ^{(Hale, LactMed, Briggs 2015, Schaefer 2015, Howie 2006)}