Last update Dec. 30, 2021

(2-{4-[(R)-p-Chloro-α-phenylbenzyl]-1-piperazinyl}ethoxy)acetic acid

Likely Compatibility

Fairly safe. Mild or unlikely adverse effects. Compatible under certain circumstances. Follow-up recommended. Read Commentary.

Second generation antihistamine, derived from piperazine, with minimal sedative effects and very low toxicity even at high doses.

Since the last update we have not found published data on its excretion in breast milk, but it is an enantiomer and active metabolite of cetirizine, that It is excreted in breast milk in clinically insignificant amounts (Wilkerson 2021). No problems were detected in the short or long term in an infant whose mother took cetirizine during the first month after delivery as part of the treatment for pemphigus.(Westermann 2012)

Its high binding to plasma proteins makes its transfer to milk unlikely.

The British Society for Allergy and Clinical Immunology considers cetirizine safe during breastfeeding. (Powell 2007)


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.

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Other names

(2-{4-[(R)-p-Chloro-α-phenylbenzyl]-1-piperazinyl}ethoxy)acetic acid is Levocetirizine in Chemical name.

Is written in other languages:

(2-{4-[(R)-p-Chloro-α-phenylbenzyl]-1-piperazinyl}ethoxy)acetic acid is also known as

Group

(2-{4-[(R)-p-Chloro-α-phenylbenzyl]-1-piperazinyl}ethoxy)acetic acid belongs to this group or family:

Tradenames

Main tradenames from several countries containing (2-{4-[(R)-p-Chloro-α-phenylbenzyl]-1-piperazinyl}ethoxy)acetic acid in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 389 daltons
Protein Binding 92 %
VD 0.4 l/Kg
Tmax 1 hours
T½ 8 - 12 hours

References

  1. Wilkerson H, Datta P, Rewers-Felkins K, Baker T, Hale TW. Maternal Transfer of Cetirizine Into Human Milk. J Hum Lact. 2021 Feb;37(1):135-138. Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  3. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)
  4. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)

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