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It is a potent opioid agonist-antagonist analgesic used for the relief of moderate to severe pain, including labor pain, and as an adjunct to anesthesia. Administration by intravenous, intramuscular, or intranasal routes.
It is excreted in breast milk in negligible amount. (Pittman 1980)
The time of onset of breastfeeding was delayed in newborns whose mothers received analgesia at delivery with butorphanol or nalbuphine compared to those who did not receive analgesia, although in both groups it occurred on average within the first hour after birth. (Crowell 1994)
Expert authors consider the use of this medication during lactation to be probably compatible. (Hale, Reece 2017, Briggs 2015, Sachs 2013). American Academy of Pediatrics: medication usually compatible with breastfeeding.(AAP 2001)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.