Last update April 18, 2022
Very Low Risk
Suggestions made at e-lactancia are done by APILAM team of health professionals, and are based on updated scientific publications. It is not intended to replace the relationship you have with your doctor but to compound it. The pharmaceutical industry contraindicates breastfeeding, mistakenly and without scientific reasons, in most of the drug data sheets.
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11β,17α,21-Trihydroxypregn-4-ene-3,20-dione is Hydrocortisone, systemic use in Chemical name.Is written in other languages:
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione is also known as
11β,17α,21-Trihydroxypregn-4-ene-3,20-dione belongs to these groups or families:
Main tradenames from several countries containing 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione in its composition:
|VD||0.48 - 1||l/Kg|
|T½||1 - 2||hours|
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e-lactancia is a resource recommended by Asociación Pro Lactancia Materna (APROLAM) of Mexico
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM
Hydrocortisone or cortisol is a natural steroid produced in the adrenal cortex. It has glucocorticoid and, to a lesser extent, mineralocorticoid effects. Its esters are used as anti-inflammatories orally, intramuscularly, intravenously, intraarticularly and topically (dermatological, intestinal, ophthalmic and otic).
At the date of the last update we did not find any published data on its excretion in breast milk.
Its pharmacokinetic data (high percentage of protein binding, wide volume of distribution and short half-life) make it highly unlikely that significant quantities will pass into breast milk.
Cortisol is a normal component of breast milk. Its concentration, 7 mcg/L (0.2 - 32) (Kulski 1981), has a circadian rhythm (Italianer 2020) and can increase in situations of maternal stress. (Aparicio 2020)
Intra-articular administration of depot prednisone derivatives may be a cause of transient decrease of milk production (Smuin 2016, McGuire 2012, Babwah 2013)
Until more published data is known about this drug in relation to breastfeeding, known safer alternatives are preferable, especially during the neonatal period and in the event of prematurity.
Eleventh WHO Model List of Essential Drugs 2002: Compatible with breastfeeding in single dose. No data available about prolonged usage. (WHO 2002)
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