Last update: Oct. 9, 2016

Vitamin A Acid (topical use)

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Retinoid, an acid form of vitamin A.

At latest update no published data on excretion into breast milk were found.
It is a normal component of breastmilk.

Because of the small dose used and poor absorption into plasma of most topical dermatological preparations, excretion into breastmilk in significant amount appears to be unlikely.

Do not apply on the breast, otherwise, wash it off thoroughly before next feed.

Systemic use (overall as an antineoplastic drug) while breastfeeding is absolutely contraindicated.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Vitamin A Acid (topical use) is also known as Tretinoin (topical use). Here it is a list of alternative known names::


Vitamin A Acid (topical use) in other languages or writings:

Group

Vitamin A Acid (topical use) belongs to this group or family:

Tradenames

Main tradenames from several countries containing Vitamin A Acid (topical use) in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Derm: 5 - 7 %
Molecular weight 300 daltons
Protein Binding 95 %
Tmax 2 hours
T1/2 2 hours

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Leachman SA, Reed BR. The use of dermatologic drugs in pregnancy and lactation. Dermatol Clin. 2006 Abstract
  3. Morland-Schultz K, Hill PD. Prevention of and therapies for nipple pain: a systematic review. J Obstet Gynecol Neonatal Nurs. 2005 Abstract
  4. Akhavan A, Bershad S. Topical acne drugs: review of clinical properties, systemic exposure, and safety. Am J Clin Dermatol. 2003 Abstract
  5. van Hoogdalem EJ. Transdermal absorption of topical anti-acne agents in man; review of clinical pharmacokinetic data. J Eur Acad Dermatol Venereol. 1998 Abstract

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