Last update: Jan. 15, 2021


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Sulfonylurea that stimulates endogenous insulin secretion. May cause hypoglycemia.
Indicated in the treatment of type 2 diabetes.
Oral administration in one to three doses daily.

It is excreted in breast milk in clinically insignificant amounts (Moiel 1967).

Experts authors consider the use of this medication to be safe during breastfeeding (Serrano 2015).
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).

Diet, exercise, and breastfeeding improve blood sugar levels.

See below the information of this related product:


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tolbutamide is also known as

Tolbutamide in other languages or writings:


Main tradenames from several countries containing Tolbutamide in its composition:


Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 270 daltons
Protein Binding 95 %
VD 0,1 l/Kg
pKa 4,3 -
Tmax 3 - 5 hours
T1/2 4,5 - 6,5 hours
M/P ratio 0,4 -
Theoretical Dose 0.00045 - 0.0027 mg/Kg/d
Relative Dose 0.004% - 0.02% %


  1. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  2. Mylan Ph. Tolbutamide. Drug Summary. 2009 Full text (in our servers)
  3. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  4. Moiel RH, Ryan JR. Tolbutamide orinase in human breast milk. Clin Pediatr (Phila). 1967 Aug;6(8):480. No abstract available. Abstract

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e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece

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