Last update: Aug. 4, 2014

Tolbutamide

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Sulfonilurea drugs stimulate secretion of endogen insulin. Oral anti-diabetic drugs are useless for treatment of diabetes type 1. For diabetes type 2, diet and exercise are advisable. Breastfeeding helps to lower glucemia level. See section on Maternal diabetes mellitus

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tolbutamide is also known as


Tradenames

Main tradenames from several countries containing Tolbutamide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 270 daltons
Protein Binding 90 %
Tmax 3,5 hours
T1/2 6,5 hours
M/P ratio 0,4 -
Theoretical Dose 0,002 mg/Kg/d
Relative Dose 0,05 %

References

  1. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  2. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)

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e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana from Spain

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