Last update: July 2, 2015

Tigecycline

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

On latest update no relevant data related to breastfeeding were found.

Pharmacokinetic data (wide distribution volume, moderately high molecular weight and high protein binding) suggest that excretion into breast milk would not be significant.

Even more, low oral bioavailability makes absorption from ingested breast milk into infant’s blood be nil or scanty. However, in premature infants and neonates in early postpartum, blood levels are likely higher due to increased gut absorption.

Nonetheless, a safer alternative with other known antibiotic is preferred until more information is available.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Tigecycline in other languages or writings:

Group

Tigecycline belongs to this group or family:

Tradenames

Main tradenames from several countries containing Tigecycline in its composition:

References

  1. PDR Tygacil _ Drug Summary PDR 2014 Full text (link to original source) Full text (in our servers)
  2. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  3. CUN Tigeciclina Fiche técnica 2007 Full text (link to original source) Full text (in our servers)
  4. HGUA Tigeciclina Ficha técnica 2007 Full text (link to original source) Full text (in our servers)
  5. Agwuh KN, MacGowan A. Pharmacokinetics and pharmacodynamics of the tetracyclines including glycylcyclines. J Antimicrob Chemother. 2006 Abstract Full text (link to original source) Full text (in our servers)
  6. Muralidharan G, Micalizzi M, Speth J, Raible D, Troy S. Pharmacokinetics of tigecycline after single and multiple doses in healthy subjects. Antimicrob Agents Chemother. 2005 Abstract Full text (link to original source) Full text (in our servers)
  7. Meagher AK, Ambrose PG, Grasela TH, Ellis-Grosse EJ. The pharmacokinetic and pharmacodynamic profile of tigecycline. Clin Infect Dis. 2005 Abstract Full text (link to original source) Full text (in our servers)

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