Last update: Aug. 12, 2014

Aztreonam

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Monobactamic antibiotic which is similar to penicillins.

It is excreted into breast milk in insignificant amount. Not absorbed by the intestine.

No adversed effects on breastfed babies have been reported.

It is commonly prescribed to children and newborns.

Be aware of false negative bacterial cultures in the infant when the mother is on antibiotics.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding

Alternatives

We do not have alternatives for Aztreonam since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Aztreonam belongs to this group or family:

Tradenames

Main tradenames from several countries containing Aztreonam in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 1 %
Molecular weight 435 daltons
Protein Binding 56 %
VD 0,16 - 0,42 l/Kg
Tmax 0,6 - 1,3 hours
T1/2 1,7 hours
M/P ratio 0,01 -
Theoretical Dose 0,15 mg/Kg/d
Relative Dose 0,18 - 0,45 %
Relat.Ped.Dose 0,125 %

References

  1. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  2. Ito K, Hirose R, Tamaya T, Yamada Y, Izumi K. [Pharmacokinetic and clinical studies on aztreonam in the perinatal period]. Jpn J Antibiot. 1990 \ Apr;43(4):719-26. 1990 Abstract
  3. Mattie H. Clinical pharmacokinetics of aztreonam. Clin Pharmacokinet. 1988 Mar;14(3):148-55. 1988 Abstract
  4. Nau H. Clinical pharmacokinetics in pregnancy and perinatology. II. Penicillins. Dev Pharmacol Ther. 1987 Abstract
  5. Fleiss PM, Richwald GA, Gordon J, Stern M, Frantz M, Devlin RG. Aztreonam in human serum and breast milk. Br J Clin Pharmacol. 1985 Abstract Full text (in our servers)

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