Last update: Jan. 17, 2016

Thiocolchicoside

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T½.
Read the Comment.

Muscle-relaxant drug which is marketed in some countries and usually associated to acetaminophen.

At latest update no published data were found on excretion into breast milk.

Pharmacokinetic data favor excretion into breast milk.

Convulsions have been reported in susceptible persons. There is a warning on likely mutagenic effects with a prolonged use.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Thiocolchicoside in other languages or writings:

Group

Thiocolchicoside belongs to this group or family:

Tradenames

Main tradenames from several countries containing Thiocolchicoside in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 25 %
Molecular weight 564 daltons
Protein Binding 13 %
VD 0,4 - 0,6 l/Kg
Tmax 0,5 - 1 hours
T1/2 1,5 - 7 hours

References

  1. AEMPS. Tiocolchicosido. Ficha técnica 2015 Full text (in our servers)
  2. EMA. La Agencia Europea de Medicamentos recomienda restringir el uso del tiocolchicósido por vía oral o inyectable. 2014 Full text (in our servers)
  3. EMA. Thiocolchicoside. Drug Summary. 2013 Full text (in our servers)
  4. EMA. European Medicines Agency recommends restricting use of thiocolchicoside by mouth or injection. 2013 Full text (in our servers)
  5. Giavina-Bianchi P, Giavina-Bianchi M, Tanno LK, Ensina LF, Motta AA, Kalil J. Epileptic seizure after treatment with thiocolchicoside. Ther Clin Risk Manag. 2009 Abstract
  6. De Riu PL, Rosati G, Sotgiu S, Sechi G. Epileptic seizures after treatment with thiocolchicoside. Epilepsia. 2001 Abstract
  7. Sandouk P, Chappey O, d'Yvoire MB, Scherrmann JM. Pharmacokinetics of thiocolchicoside in humans using a specific radioimmunoassay. Ther Drug Monit. 1995 Abstract
  8. Perucca E, Poitou P, Pifferi G. Comparative pharmacokinetics and bioavailability of two oral formulations of thiocolchicoside, a GABA-mimetic muscle relaxant drug, in normal volunteers. Eur J Drug Metab Pharmacokinet. 1995 Abstract
  9. Sandouk P, Bouvier d'Yvoire M, Chretien P, Tillement JP, Scherrmann JM. Single-dose bioavailability of oral and intramuscular thiocolchicoside in healthy volunteers. Biopharm Drug Dispos. 1994 Abstract

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