Last update: July 2, 2015

Baclofen

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Centrally acting Myorelaxant.

Indicated for spastic disorders associated with degenerative illnesses and cerebral palsy.

Excreted into breast milk in non-significant clinical amount with no harm effects reported among breastfed infants from treated mothers.

When administered in pregnancy, symptoms of Abstinence Syndrome may appear,

Intrathecal administration shows small serum levels by which it is assumed that the amount present in breast milk must be even lower.

Oral administration has been authorized since neonatal age in the UK and one year of life in Spain.

Follow-up of milk production is recommended since a theoretically based inhibition of Prolactin may occur.

American Academy of Pediatrics: medication usually compatible with breastfeeding.

Alternatives

We do not have alternatives for Baclofen since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Baclofen in other languages or writings:

Group

Baclofen belongs to this group or family:

Tradenames

Main tradenames from several countries containing Baclofen in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 214 daltons
Protein Binding 30 %
VD 0,8 l/Kg
Tmax 0,5 - 3 hours
T1/2 2,5 - 4 hours
M/P ratio 0,7 -
Theoretical Dose 0,0207 mg/Kg/d
Relative Dose 1,7 - 8,3 %
Relat.Ped.Dose 1,0 - 2,8 %

References

  1. Almas S, Vance J, Baker T, Hale T. Management of Multiple Sclerosis in the Breastfeeding Mother. Mult Scler Int. 2016 Abstract Full text (link to original source) Full text (in our servers)
  2. AEMPS Baclofeno intratecal Ficha técnica 2012 Full text (link to original source) Full text (in our servers)
  3. IQB Baclofeno oral Ficha técnica 2008 Full text (link to original source) Full text (in our servers)
  4. Omari TI, Benninga MA, Sansom L, Butler RN, Dent J, Davidson GP. Effect of baclofen on esophagogastric motility and gastroesophageal reflux in children with gastroesophageal reflux disease: a randomized controlled trial. J Pediatr. 2006 Abstract
  5. Moran LR, Almeida PG, Worden S, Huttner KM. Intrauterine baclofen exposure: a multidisciplinary approach. Pediatrics. 2004 Abstract Full text (link to original source) Full text (in our servers)
  6. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  7. Morosini PP, Carletti P, Sarzani R, Ferretti GF, Marchesi GF, Nardi B. [Prolactin after baclofen in healthy subjects and prolactinoma patients]. Boll Soc Ital Biol Sper. 1985 Abstract
  8. Eriksson G, Swahn CG. Concentrations of baclofen in serum and breast milk from a lactating woman. Scand J Clin Lab Invest. 1981 Abstract
  9. Potkin SG, Gillin JC, Rogol A, Nasrallah HA, Wyatt RJ. Baclofen: lack of effect on human plasma prolactin. Commun Psychopharmacol. 1978 Abstract

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