Last update: June 10, 2018
Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.
A 2nd generation antihistamine, derived from piperidine, with minimal sedative effects.
It is completely metabolized to fexofenadine.
Administered orally once a day.
Its high percentage of protein binding explains the negligible transfer to milk observed from fexofenadine (Lucas 1995).
In a telephone follow-up, 10% of infants whose mothers were taking terfenadine exhibited colic and irritability, which did not require treatment (Ito 1993).
American Academy of Pediatrics: medication usually compatible with breastfeeding (AAP 2001).
It has been withdrawn from sale in most countries due to serious cardiac arrhythmias when taken with many other medications and with grapefruit juice (Benton 1996, Smith 1994, Monahan 1990). Its metabolite, fexofenadine, does not cause arrhythmias.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.
Thank you for helping to protect and promote breastfeeding.
e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece
Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM