Last update: Aug. 6, 2021

Cetirizine Hydrochloride

Very Low Risk for breastfeeding


Safe. Compatible.
Minimal risk for breastfeeding and infant.

A second generation antihistamine, derived from piperazine and hydroxyzine metabolite, with minimal sedative effects and very low toxicity even at high doses.
Indicated in allergic rhinitis and chronic urticaria.
Oral administration in a single daily dose.

It is excreted in breast milk in clinically insignificant amounts (Wilkerson 2021).
Their pharmacokinetic data (high volume of distribution and high percentage of plasma protein binding) probably explain the negligible excretion observed in breast milk.
No problems in the short or long term have been observed in infants whose mothers have taken it (Wilkerson 2021, Gashlin 2016, Westermann 2012).

Cetirizine has been used in nursing mothers to treat persistent neuropathic breast pain (Muddana 2018).

The British Society for Allergy and Clinical Immunology and other experts consider it safe during breastfeeding (Hale, Middleton 2020, Briggs 2015, Schaefer 2015, Butler 2014, Powell 2007).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cetirizine Hydrochloride is also known as


Cetirizine Hydrochloride in other languages or writings:

Group

Cetirizine Hydrochloride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cetirizine Hydrochloride in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 70 %
Molecular weight 462 daltons
Protein Binding 93 %
VD 0,56 l/Kg
pKa 3,36 -
Tmax 1 - 2,2 hours
T1/2 8,3 hours
Theoretical Dose 0,003 - 0,007 mg/Kg/d
Relative Dose 1,7 - 4,1 %

References

  1. Wilkerson H, Datta P, Rewers-Felkins K, Baker T, Hale TW. Maternal Transfer of Cetirizine Into Human Milk. J Hum Lact. 2021 Feb;37(1):135-138. Abstract
  2. Middleton PG, Gade EJ, Aguilera C, MacKillop L, Button BM, Coleman C, Johnson B, Albrechtsen C, Edenborough F, Rigau D, Gibson PG, Backer V. ERS/TSANZ Task Force Statement on the management of reproduction and pregnancy in women with airways diseases. Eur Respir J. 2020 Feb 6;55(2). pii: 1901208. Abstract Full text (link to original source) Full text (in our servers)
  3. Muddana A, Asbill DT, Jerath MR, Stuebe AM. Quantitative Sensory Testing, Antihistamines, and Beta-Blockers for Management of Persistent Breast Pain: A Case Series. Breastfeed Med. 2018 May;13(4):275-280. Abstract
  4. Gashlin LZ, Sullo D, Lawrence RA, Rosen-Carole C. Treatment of Narcolepsy with Sodium Oxybate While Breastfeeding: A Case Report. Breastfeed Med. 2016 Jun;11:261-3. Abstract
  5. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. Tenth edition (acces on line) 2015
  6. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  7. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Feb;39(2):168-71. Abstract
  8. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)
  9. del Cuvillo A, Mullol J, Bartra J, Dávila I, Jáuregui I, Montoro J, Sastre J, Valero AL. Comparative pharmacology of the H1 antihistamines. J Investig Allergol Clin Immunol. 2006;16 Suppl 1:3-12. Review. No abstract available. Abstract Full text (link to original source) Full text (in our servers)
  10. Hale TW. Hale's Medications & Mothers' Milk. [Internet]. Springer Publishing Company; 1991-. Available from: https://www.halesmeds.com None

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