Last update: March 23, 2018

Cétirizine, Chlorhydrate de

Very Low Risk for breastfeeding


Compatible.
Not risky for breastfeeding or infant.

A second generation antihistamine, derived from piperazine and hydroxyzine metabolite, with minimal sedative effects and very low toxicity even at high doses.

No problems were detected in the short or long term in an infant whose mother took it during the first month after delivery as part of the treatment for pemphigus (Westermann 2012).

Its high binding to plasma proteins makes its transfer to milk very unlikely.

The British Society for Allergy and Clinical Immunology and other experts consider it safe during breastfeeding (Butler 2014, Powell 2007).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
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Other names

Cétirizine, Chlorhydrate de is Cetirizine Hydrochloride in French.

Is written in other languages:

Cétirizine, Chlorhydrate de is also known as

Group

Cétirizine, Chlorhydrate de belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cétirizine, Chlorhydrate de in its composition:

List of 11 tradenames

Pharmacokinetics

Variable Value Unit
Bioavailability 70 %
Molecular weight 462 daltons
Protein Binding 93 %
VD 0,56 l/Kg
pKa 3,36 -
Tmax 1 - 2,2 hours
T1/2 8,3 hours

References

  1. Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol. 2014 Mar;70(3):417.e1-10; quiz 427. Abstract
  2. Westermann L, Hügel R, Meier M, Weichenthal M, Zillikens D, Gläser R, Schmidt E. Glucocorticosteroid-resistant pemphigoid gestationis: successful treatment with adjuvant immunoadsorption. J Dermatol. 2012 Abstract
  3. Powell RJ, Du Toit GL, Siddique N, Leech SC, Dixon TA, Clark AT, Mirakian R, Walker SM, Huber PA, Nasser SM; British Society for Allergy and Clinical Immunology (BSACI). BSACI guidelines for the management of chronic urticaria and angio-oedema. Clin Exp Allergy. 2007 Abstract Full text (link to original source) Full text (in our servers)

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