Last update: June 3, 2019

Procaine Hydrochloride

Low Risk for breastfeeding

Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

At latest update no published data on excretion into breast milk was found.

Topical anesthetics (dermatological and mouth preparations when correctly applied like creams, subcutaneous injections for infiltration or spinal anesthesia) have negligible systemic absorption.
Pharmacokinetic data (poor absorption and short half-life span) make it highly unlikely the passage into milk in significant amount.

Having been published less experience than with other drugs of the same group, it would be preferable the use of a known safer alternative, especially during the neonatal period and in case of premature birth.


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Procaine Hydrochloride is also known as

Procaine Hydrochloride in other languages or writings:


Main tradenames from several countries containing Procaine Hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. Baja - Poor %
Molecular weight 273 daltons
Protein Binding 6 %
pKa 8,05 -
T1/2 0,13 hours


  1. AEMPS - Serra. Procaína. Ficha técnica. 2007 Full text (in our servers)
  2. Hospira. Procaine (Novocain). Drug Summary. 2007 Full text (in our servers)
  3. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  4. Inoue M, Morikawa M, Tsuboi M, Ito Y, Sugiura M. Comparative study of human intestinal and hepatic esterases as related to enzymatic properties and hydrolizing activity for ester-type drugs. Jpn J Pharmacol. 1980 Aug;30(4):529-35. Abstract
  5. Seifen AB, Ferrari AA, Seifen EE, Thompson DS, Chapman J. Pharmacokinetics of intravenous procaine infusion in humans. Anesth Analg. 1979 Sep-Oct;58(5):382-6. Abstract

Total visits


Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write to us at

e-lactancia is a resource recommended by Asociación Española de Bancos de Leche Humana from Spain

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM