Last update: June 2, 2019
Not risky for breastfeeding or infant.
Local anesthetic type amide, generally associated with epinephrine, used in dental anesthesia, local and regional (infiltration and epidural).
At the date of last revision, we did not find data published in relation to breastfeeding.
It is hydrolyzed immediately to inactive articainic acid (van Oss 1989 and 1988), so no systemic toxicity is observed (AEMPS 2019, FDA 2006), not even after unintentional systemic injection (Oertel 1997).
In addition, its short elimination half-life and its large volume of distribution would prevent excretion in breast milk of a significant amount.
According to the manufacturer, it is not necessary to suspend breastfeeding since there are no clinically relevant levels in breast milk (AEMPS 2019).
If ingested orally, it is rapidly hydrolysed by gastric esterases, which would prevent it from reaching infant plasma from ingested breast milk (Hale 2019).
Due to its characteristics, it is the local anesthetic of choice during lactation for dental and infiltration procedures (Nizharadze 2011).
We do not have alternatives for Articaine Hydrochloride since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
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