Last update: Sept. 24, 2015

Piroxicam

Very Low Risk for breastfeeding


Compatible.
Not risky for breastfeeding or infant.

It is excreted in breast milk in clinically non-significant amount and no problems have been observed in infants whose mothers took this medication. Levels in plasma and urine of such infants were undetectable.

Having published less quantity of studies than with other drugs of the same group, safer alternatives may be preferable, especially in the neonatal period and in case of prematurity.

The American Academy of Pediatrics rates it as usually compatible with breastfeeding.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Piroxicam in other languages or writings:

Pharmacokinetics

Variable Value Unit
Bioavailability 100 %
Molecular weight 331 daltons
Protein Binding 99 %
VD 0,14 l/Kg
Tmax 3 - 5 hours
T1/2 50 hours
M/P ratio 0,01 -
Theoretical Dose 0,01 - 0,03 mg/Kg/d
Relative Dose 3 - 4,5 %
Relat.Ped.Dose 3,3 - 5 %

References

  1. Pfizer, S.L. Piroxicam. Ficha técnica. 2012 Full text (in our servers)
  2. FDA. Piroxicam. Drug Summary. 2012 Full text (in our servers)
  3. Østensen M, Motta M. Therapy insight: the use of antirheumatic drugs during nursing. Nat Clin Pract Rheumatol. 2007 Abstract
  4. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  5. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  6. Goldsmith DP. Neonatal rheumatic disorders. View of the pediatrician. Rheum Dis Clin North Am. 1989 Abstract
  7. Ostensen M, Matheson I, Laufen H. Piroxicam in breast milk after long-term treatment. Eur J Clin Pharmacol. 1988 Abstract
  8. Ostensen M. Piroxicam in human breast milk. Eur J Clin Pharmacol. 1983 Abstract

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