Last update: Nov. 24, 2020
Minimal risk for breastfeeding and infant.
It is composed by a complex mixture of phospholipids (phosphatidylcholine, phosphatidylserine, phosphatidylinositol) as a part of cell membranes and found in large amounts in the seed oil of several plants (soy, sunflower, and colza), egg yolk and liver.
They are used in the food and pharmaceutical industry as softener and stabilizer. Also, as a medication for hyperlipidemia control. It has been also added to pumped breast milk to lessen loss of fat due to adherence to the surface of tubes used for enteral feeding (Chan 2003).
It is naturally found in the plasma, and, at higher levels in human milk. The mature milk contains more Coline than the colostrum or the mother milk of prematures (Ilcol 2005, Holmes 2000 y 1996). This content is also higher in breast milk than in industrial formulas (Holmes 1996).
When used as a supplement, the concentration of Coline is moderately increased in the plasma, the milk and the serum of the infant (Davenport 2015, Fischer 2010). Supplementation with Coline does not enhance the cognitive capability of the infant (Cheatham 2012).
It is used in the treatment of mastitis, blocked ducts, nipple blisters or milk blebs (Zheng 2020, McGuire 2015, Scott 2005), although there is not scientific evidence of its effectiveness.
No adverse effects have been reported. Since a lack of toxicity at usual doses, it is believed to be safe while breastfeeding with a moderate use.
We do not have alternatives for Phosphatidyl-serine since it is relatively safe.
Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.
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