Last update: June 26, 2020

Phenelzine Sulfate

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Antidepressant used in the treatment of atypical depression.
Oral administration 3 to 4 times a day.

Since the last update we have not found any published data on its excretion in breast milk.

It can cause galactorrhea (Segal 1969).

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in cases of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Phenelzine Sulfate in other languages or writings:

Group

Phenelzine Sulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Phenelzine Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. Alta - Hig %
Molecular weight 136 daltons
pKa 6,5 - 8 -
Tmax 0,7 - 4 hours
T1/2 1,5 - 11,5 hours

References

  1. Pfizer. Phenelzine (Nardil). Drug Summary. 2009 Full text (in our servers)
  2. Baker GB, Urichuk LJ, McKenna KF, Kennedy SH. Metabolism of monoamine oxidase inhibitors. Cell Mol Neurobiol. 1999 Jun;19(3):411-26. Review. Abstract
  3. Segal M, Heys RF. Inappropriate lactation. Br Med J. 1969 Oct 25;4(5677):236. No abstract available. Abstract

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