Last update: May 13, 2019

Phenazone

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

An analgesic and pyrazolone derivative which inhibits prostaglandin synthesis.
It has been used as an analgesic and systemic antipyretic but given the frequency and severity of its side effects, the majority of products currently on the market are made for dermatological or otological topical application.

Administered orally to mothers, it is excreted in breastmilk in amounts which could be significant (Berlin 1982).

Hemolytic anemia has been observed in a newborn whose mother was taking a phenazone derivative (Frei 1985).

Systemic use (orally) is contraindicated during breastfeeding.

TOPICAL USE:
The small dose and low plasma absorption of most topical dermatological and otic preparations make it unlikely that it will transfer into breastmilk in significant amounts.
Topical use is compatible with breastfeeding.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

Phenazone is also known as


Phenazone in other languages or writings:

Groups

Phenazone belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Phenazone in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 188 daltons
Protein Binding < 10 %
VD 0,6 l/Kg
Tmax 1 - 2 hours
T1/2 6 - 20 hours
M/P ratio 1 -
Theoretical Dose 0,56 - 3,1 mg/Kg/d
Relative Dose 3,1 - 17,2 %

References

  1. Frei H, Bühlmann U, Rudin O. [Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk]. Z Geburtshilfe Perinatol. 1985 Jan-Feb;189(1):11-2. German. Abstract
  2. Berlin CM Jr, Vesell ES. Antipyrine disposition in milk and saliva of lactating women. Clin Pharmacol Ther. 1982 Jan;31(1):38-44. Abstract

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