Last update: Nov. 29, 2019

Modafinil

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

Estimulante central inhibidor selectivo de la recaptación de dopamina y noradrenalina.
El modafinilo es un mezcla racémica de su enantiomero R y su enantiomero S. El enantiomero R, conocido como Armodafinilo, es farmacológicamente activo, mientras que el enantiomero S es inactivo (Aurora 2018).
Utilizado en la narcolepsia.
Administración oral en una o dos dosis diarias.

El modafinilo se excreta en leche materna en cantidad clínicamente no significativa (Aurora 2018) y no se han observado problemas en seis lactantes cuyas madres tomaban modafinilo (Calvo 2018).

El modafinilo puede reducir los niveles de prolactina (Samuels 2006).

Una madre nos ha comunicado nerviosismo y dificultad para dormir en sus hijas lactantes que le obligó a suspender el tratamiento (edad de niñas y dosis no especificadas).

Hasta conocer más datos publicados sobre este fármaco en relación con la lactancia, pueden ser preferibles alternativas conocidas más seguras, especialmente durante el periodo neonatal y en caso de prematuridad.


See below the information of these related products:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Modafinil in other languages or writings:

Group

Modafinil belongs to this group or family:

Tradenames

Main tradenames from several countries containing Modafinil in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 100 %
Molecular weight 273 daltons
Protein Binding 60 %
VD 0,9 l/Kg
pKa 8,84 -
Tmax 2 - 4 hours
T1/2 15 hours
Theoretical Dose 0,18 mg/Kg/d
Relative Dose 5,3 %

References

  1. AEMPS. Modafinilo. Ficha técnica. 2019 Full text (in our servers)
  2. Calvo-Ferrandiz E, Peraita-Adrados R. Narcolepsy with cataplexy and pregnancy: a case-control study. J Sleep Res. 2018 Apr;27(2):268-272. Abstract Full text (link to original source)
  3. Aurora S, Aurora N, Datta P, Rewers-Felkins K, Baker T, Hale TW. Evaluating Transfer of Modafinil Into Human Milk During Lactation: A Case Report. J Clin Sleep Med. 2018 Dec 15;14(12):2087-2089. Abstract Full text (link to original source) Full text (in our servers)
  4. FDA. Modafinil (Provigil). Drug Summary. 2010 Full text (link to original source) Full text (in our servers)
  5. Wise MS, Arand DL, Auger RR, Brooks SN, Watson NF; American Academy of Sleep Medicine. Treatment of narcolepsy and other hypersomnias of central origin. Sleep. 2007 Abstract Full text (link to original source) Full text (in our servers)

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