Last update: June 2, 2019

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride

Very Low Risk for breastfeeding

Safe. Compatible.
Not risky for breastfeeding or infant.

Local anesthetic type amide, generally associated with epinephrine, used in dental anesthesia, local and regional (infiltration and epidural).

At the date of last revision, we did not find data published in relation to breastfeeding.

It is hydrolyzed immediately to inactive articainic acid (van Oss 1989 and 1988), so no systemic toxicity is observed (AEMPS 2019, FDA 2006), not even after unintentional systemic injection (Oertel 1997).

In addition, its short elimination half-life and its large volume of distribution would prevent excretion in breast milk of a significant amount.

According to the manufacturer, it is not necessary to suspend breastfeeding since there are no clinically relevant levels in breast milk (AEMPS 2019).

If ingested orally, it is rapidly hydrolysed by gastric esterases, which would prevent it from reaching infant plasma from ingested breast milk (Hale 2019).

Due to its characteristics, it is the local anesthetic of choice during lactation for dental and infiltration procedures (Nizharadze 2011).

See below the information of this related product:


We do not have alternatives for Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride is Articaine Hydrochloride in Chemical name.

Is written in other languages:

Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride is also known as


Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride belongs to this group or family:


Main tradenames from several countries containing Methyl 4-methyl-3-(2-propylaminopropionamido)thiophene-2-carboxylate hydrochloride in its composition:


Variable Value Unit
Oral Bioavail. baja - poor %
Molecular weight 321 daltons
Protein Binding 53 - 73 %
VD 1,67 - 2,69 l/Kg
pKa 4,42 -
Tmax 0,25 hours
T1/2 0,3 (epidural: 0,5 - 2,2) hours


  1. AEMPS - Normon. Articaína (Ultracaín). Ficha técnica. 2019 Full text (in our servers)
  2. Nizharadze N, Mamaladze M, Chipashvili N, Vadachkoria D. Articaine - the best choice of local anesthetic in contemporary dentistry. Georgian Med News. 2011 Abstract
  3. FDA. Artisane (Septocaine). Drug Summary. 2006 Full text (in our servers)
  4. Oertel R, Rahn R, Kirch W. Clinical pharmacokinetics of articaine. Clin Pharmacokinet. 1997 Abstract
  5. van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Pharmacokinetics, metabolism, and renal excretion of articaine and its metabolite articainic acid in patients after epidural administration. Eur J Anaesthesiol. 1989 Abstract
  6. Van Oss GE, Vree TB, Baars AM, Termond EF, Booij LH. Clinical effects and pharmacokinetics of articainic acid in one volunteer after intravenous administration. Pharm Weekbl Sci. 1988 Abstract

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e-lactancia is a resource recommended by Instituto de Salud Infantil, Grecia-Institute of Child's Health in Greece

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