Last update: Aug. 20, 2017

Liraglutide

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Glucagon-like peptide 1 analogue that stimulates endogenous insulin secretion.
Used to treat obesity and type 2 diabetes in combination with other oral antidiabetics, especially metformin.
Administered subcutaneously.
The most common side effects are nausea, vomiting and diarrhea. Low risk of hypoglycemia in monotherapy.

Since the last update we have not found published data on its excretion in breast milk.

Its pharmacokinetic data (high molecular weight and high percentage of plasma protein binding) make it very unlikely that significant amounts will pass into breast milk (Serrano 2014).

Due to its protein nature, it deteriorates in the gastrointestinal tract, not being absorbed (Serrano 2014). This low oral bioavailability would make it difficult for it to pass to the infant’s plasma ingesting breast milk, except in preterm infants and in the immediate neonatal period when there may be increased intestinal permeability.

Diet, exercise, and breastfeeding improve blood sugar levels.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Liraglutide in other languages or writings:

Tradenames

Main tradenames from several countries containing Liraglutide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 0 %
Molecular weight 3751 daltons
Protein Binding 98 %
VD 0,07 l/Kg
Tmax 8 - 12 hours
T1/2 13 hours

References

  1. EMA. Liraglutide. Drug Summary. 2016 Full text (in our servers)
  2. EMA. Liraglutida. Ficha técnica. 2016 Full text (in our servers)
  3. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract

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