Last update: May 11, 2019

Linézolide

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

An antibacterial oxazolidinone, indicated in the treatment of skin, soft tissue and lung infections by Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin.
Oral or intravenous administration every 12 hours.
Its use is authorized in small infants and neonates.

It is excreted in breastmilk in moderate amounts which could be significant (Lim 2017, Rowe 2014, Sagirli 2009), but it is less than one tenth of the dose used in neonates and infants.

Possible side effects are not serious or frequent.

Several experts believe that the use of this medication is probably compatible during breastfeeding (Briggs 2017, Hale 2017 p563).

Be aware of false negative results of bacterial cultures obtained from febrile infants whose mothers are on antibiotics, as well as the possibility of gastroenteritis due to altered intestinal flora (Briggs 2017, Ito 1993).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Linézolide is Linezolid in French.

Is written in other languages:

Group

Linézolide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Linézolide in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 100 %
Molecular weight 337 daltons
Protein Binding 31 %
VD 0,7 l/Kg
pKa 14,45 -
Tmax 1 - 2 hours
T1/2 5 -7 hours
Theoretical Dose 0,53 - 2,8 mg/Kg/d
Relative Dose 2,6 - 14 %
Relat.Ped.Dose 1,7 - 9,3 %

References

  1. AEMPS-Accordpharma. Linezolid. Ficha técnica. 2018 Full text (in our servers)
  2. Lim FH, Lovering AM, Currie A, Jenkins DR. Linezolid and lactation: measurement of drug levels in breast milk and the nursing infant. J Antimicrob Chemother. 2017 Abstract
  3. Rowe HE, Felkins K, Cooper SD, Hale TW. Transfer of linezolid into breast milk. J Hum Lact. 2014 Abstract
  4. Mitrano JA, Spooner LM, Belliveau P. Excretion of antimicrobials used to treat methicillin-resistant Staphylococcus aureus infections during lactation: safety in breastfeeding infants. Pharmacotherapy. 2009 Sep;29(9):1103-9. Abstract
  5. Sagirli O, Onal A, Toker S, Oztunç A. Determination of linezolid in human breast milk by high-performance liquid chromatography with ultraviolet detection. J AOAC Int. 2009 Abstract
  6. Pfizer. Linezolid. Drug Summary. 2008 Full text (in our servers)
  7. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract

Total visits

104

Help us improve this entry

How to cite this entry

Do you need more information or did not found what you were looking for?

   Write to us at elactancia.org@gmail.com

e-lactancia is a resource recommended by Academy of Breastfeeding Medicine from United States of America

Would you like to recommend the use of e-lactancia? Write to us at corporate mail of APILAM