Last update: Aug. 12, 2018

Levothyroxine

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

It should be taken into account whenever screening test are done in neonates.

No problems have been reported when the usual therapeutic substitutive dosage is used to keep the mother euthyroid. Follow-up thyroid function cautiously in the infant when a higher suppressive dosage is used. Under latter conditions, a lack of ejection reflex despite an appropriate milk production has been observed in animals.

American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding.

Alternatives

We do not have alternatives for Levothyroxine since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Levothyroxine belongs to this group or family:

Tradenames

Main tradenames from several countries containing Levothyroxine in its composition:

  • Bitiron™. Contains other elements than Levothyroxine in its composition
  • Combithyrex™. Contains other elements than Levothyroxine in its composition
  • Cynoplus™. Contains other elements than Levothyroxine in its composition
  • Dexnon
  • Diotroxin™. Contains other elements than Levothyroxine in its composition
  • Dithyron™. Contains other elements than Levothyroxine in its composition
  • Eltroxin
  • Euthyral™. Contains other elements than Levothyroxine in its composition
  • Eutirox
  • Eutroid™. Contains other elements than Levothyroxine in its composition
  • Levaxin
  • Levothroid
  • Levotrin™. Contains other elements than Levothyroxine in its composition
  • Liotrix Tablets USP 39™. Contains other elements than Levothyroxine in its composition
  • Novothyral™. Contains other elements than Levothyroxine in its composition
  • Novotiral™. Contains other elements than Levothyroxine in its composition
  • Oroxine
  • Prothyrid™. Contains other elements than Levothyroxine in its composition
  • Synthroid
  • Tetroid
  • Thyrolar™. Contains other elements than Levothyroxine in its composition
  • Tiroide Amsa™. Contains other elements than Levothyroxine in its composition
  • Tirosint
  • Tiroxina

Pharmacokinetics

Variable Value Unit
Bioavailability 80 %
Molecular weight 790 daltons
Protein Binding 99 %
Tmax 4 hours
T1/2 148 hours
Theoretical Dose <0,0001 mg/Kg/d
Relative Dose 0,05 %
Relat.Ped.Dose 0,01 %

References

  1. Alexander EK, Pearce EN, Brent GA, Brown RS, Chen H, Dosiou C, Grobman WA, Laurberg P, Lazarus JH, Mandel SJ, Peeters RP, Sullivan S. 2017 Guidelines of the American Thyroid Association for the Diagnosis and Management of Thyroid Disease During Pregnancy and the Postpartum. Thyroid. 2017 Abstract Full text (link to original source) Full text (in our servers)
  2. Serrano Aguayo P, García de Quirós Muñoz JM, Bretón Lesmes I, Cózar León MV. Tratamiento de enfermedades endocrinológicas durante la lactancia. [Endocrinologic diseases management during breastfeeding.] Med Clin (Barc). 2015 Abstract
  3. Stagnaro-Green A, Abalovich M, Alexander E, Azizi F, Mestman J, Negro R, Nixon A, Pearce EN, Soldin OP, Sullivan S, Wiersinga W; American Thyroid Association Taskforce on Thyroid Disease During Pregnancy and Postpartum.. Guidelines of the American Thyroid Association for the diagnosis and management of thyroid disease during pregnancy and postpartum. Thyroid. 2011 Abstract Full text (link to original source) Full text (in our servers)
  4. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Rovet JF. Does breast-feeding protect the hypothyroid infant whose condition is diagnosed by newborn screening? Am J Dis Child. 1990 Abstract
  7. Nabukhotnyĭ TK, Pavliuk VP, Gozhenko AI, Kukharchuk AL. [Role of breast feeding in providing the newborn infant with thyroid hormones]. Vopr Pitan. 1987 Abstract
  8. Oberkotter LV. Thyroid function and human breast milk. Am J Dis Child. 1983 Abstract
  9. Mallol J, Obregón MJ, Morreale de Escobar G. Analytical artifacts in radioimmunoassay of L-thyroxin in human milk. Clin Chem. 1982 Abstract Full text (link to original source) Full text (in our servers)
  10. Sato T, Suzuki Y. Presence of triiodothyronine, no detectable thyroxine and reverse triiodothyronine in human milk. Endocrinol Jpn. 1979 Abstract
  11. Bode HH, Vanjonack WJ, Crawford JD. Mitigation of cretinism by breast-feeding. Pediatrics. 1978 Abstract

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