Last update: June 27, 2021


Very Low Risk for breastfeeding

Safe. Compatible.
Minimal risk for breastfeeding and infant.

Ketoprofen is a non-steroidal anti-inflammatory drug (NSAID).
Oral, rectal, intramuscular, intravenous and topical administration every 6 to 12 hours.

It is excreted in breastmilk in clinically negligibe amounts (Jacqz-Aigrain 2007) and authors consider it compatible with breastfeeding (Davanzo 2014, Jacqz-Aigrain 2007, Janssen 2000, Nice 2000).

Its high percentage of protein binding explains the very small transfer to milk observed.

In a French pharmacovigilance study, several possible cases, unconfirmed, were found of the implication of ketoprofen in certain adverse effects in the infant (Soussan 2014). Its pharmacokinetics makes its involvement unlikely.

The small dose and the low plasma absorption of most topical dermatological preparations make transfer to breastmilk in significant amounts unlikely. Systemic bioavailability is 5% (AEMPS 2016).

Most non-steroidal anti-inflammatories may increase jaundice, so it is preferable to avoid them during the neonatal period in mothers of infants with jaundice. (Janssen 2000).

See below the information of this related product:


Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Ketoprofen in other languages or writings:


Main tradenames from several countries containing Ketoprofen in its composition:


Variable Value Unit
Oral Bioavail. 90 (Derm: 5%) %
Molecular weight 254 daltons
Protein Binding 99 %
VD 0,1 l/Kg
pKa 4,45 -
Tmax 0,5 - 4 hours
T1/2 1,5 - 4 hours
Theoretical Dose 0,009 (0,003 a 0,021) mg/Kg/d
Relative Dose 0,3 (0,14 - 0,48) %


  1. AEMPS. Ketoprofeno. Ficha técnica. 2017 Full text (in our servers)
  2. AEMPS. Ketoprofeno (uso tópico). Ficha técnica. 2016 Full text (in our servers)
  3. Soussan C, Gouraud A, Portolan G, Jean-Pastor MJ, Pecriaux C, Montastruc JL, Damase-Michel C, Lacroix I. Drug-induced adverse reactions via breastfeeding: a descriptive study in the French Pharmacovigilance Database. Eur J Clin Pharmacol. 2014 Abstract
  4. Davanzo R, Bua J, Paloni G, Facchina G. Breastfeeding and migraine drugs. Eur J Clin Pharmacol. 2014 Abstract
  5. Cherif F, El Aidli S, Kastalli S, Zaiem A, Daghfous Moula H, Lakhal M, Daghfous R. Drug induced urticaria via breastfeeding. in; Abstracts of the 13th Annual Meeting of French Society of Pharmacology and Therapeutics, 76th Annual Meeting of Society of Physiology, 30th Pharmacovigilance Meeting, 10th APNET Seminar and 7th CHU CIC Meeting, 15‐17 April 2009, Marseille, France Fundam Clin Pharmacol. 2009;23 (Suppl 1):37. Abstract 203
  6. Jacqz-Aigrain E, Serreau R, Boissinot C, Popon M, Sobel A, Michel J, Sibony O. Excretion of ketoprofen and nalbuphine in human milk during treatment of maternal pain after delivery. Ther Drug Monit. 2007 Abstract
  7. Nice FJ, Snyder JL, Kotansky BC. Breastfeeding and over-the-counter medications. J Hum Lact. 2000 Nov;16(4):319-31. Review. Erratum in: J Hum Lact 2001 Feb;17(1):90. Abstract
  8. Janssen NM, Genta MS. The effects of immunosuppressive and anti-inflammatory medications on fertility, pregnancy, and lactation. Arch Intern Med. 2000 Abstract Full text (link to original source) Full text (in our servers)
  9. De Graeve J, Frankinet C, Gielen JE. A quantitative selected ion monitoring assay for ketoprofen determination in human biological fluids. Biomed Mass Spectrom. 1979 Abstract

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