Last update: Aug. 27, 2014

Isosorbide Dinitrate

Low Risk probable for breastfeeding


Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment.

The amount of nitrates in breast milk is not related to level of contamination in drinking water (ingest <100 mg/day of nitrate do not produce milk with elevated nitrate levels). By this reason, breastfed babies from regions with nitrate contaminated water do not have increased risk of Metahemoglobinemia like bottle-fed babies do.

The amount of nitrate compounds contained in vasodilator medication is so small that no problems have been reported while breastfeeding.

Alternatives

We do not have alternatives for Isosorbide Dinitrate.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Tradenames

Main tradenames from several countries containing Isosorbide Dinitrate in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 25 %
Molecular weight 236 daltons
Protein Binding 30 %
T1/2 1 hours

References

  1. Kearney L, Wright P, Fhadil S, Thomas M. Postpartum Cardiomyopathy and Considerations for Breastfeeding. Card Fail Rev. 2018 Abstract Full text (link to original source) Full text (in our servers)
  2. WHO / UNICEF. BREASTFEEDING AND MATERNAL MEDICATION Recommendations for Drugs in the Eleventh WHO Model List of Essential Drugs. Department of Child and Adolescent Health and Development (WHO/UNICEF) 2002 Full text (link to original source) Full text (in our servers)
  3. Kirsten R, Nelson K, Kirsten D, Heintz B. Clinical pharmacokinetics of vasodilators. Part II. Clin Pharmacokinet. 1998 Abstract

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