Last update: April 19, 2018

Эстрадиол

Low Risk probable for breastfeeding


Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment.

A natural Estrogen that is marketed for oral, injection and topical administration (skin and vaginal).
On the chemical form of valerate, it is used in association with a progestin as a combined birth-control compound (e.g. Estradiol + Dienogest)

Estradiol is excreted into breast milk in clinically non-significant amount (Nilson 1978) and no problems have been observed in infants whose mothers were treated (Pinheiro 2016). Plasma levels of these infants were undetectable or very low (Pinheiro 2016). After administration in the form of transdermal patches milk levels have been undetectable (Pinheiro 2016, Perheentupa 2004). Despite these data, an older publication associated the use of transdermal estradiol with a case of jaundice and poor weight gain (Ball 1999).
There is greater passage to milk when the administration is vaginal.

There is evidence (albeit inconsistent) that estrogen-containing pills may decrease milk production, especially during the first few weeks postpartum
They may reduce the protein content of the milk.

No problems have been observed in infants whose mothers were treated, except some cases of transient gynecomastia in infants whose mothers were receiving a higher dose than usual.

Estrogen exposure in childhood or adolescence, does not influence the subsequent production of milk.

The American Academy of Pediatrics states that this medication is usually compatible with breastfeeding.


See below the information of this related product:

Alternatives

We do not have alternatives for Эстрадиол.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Эстрадиол is Estradiol in Cyrillic.

Is written in other languages:

Эстрадиол is also known as

Group

Эстрадиол belongs to this group or family:

Tradenames

Main tradenames from several countries containing Эстрадиол in its composition:

  • Activella ™. Contains other elements than Эстрадиол in its composition
  • Activelle™. Contains other elements than Эстрадиол in its composition
  • Aerodiol
  • Alcis
  • Alora (United States of America)
  • Amabelz™. Contains other elements than Эстрадиол in its composition
  • Armonil (Italy)
  • Cliane™. Contains other elements than Эстрадиол in its composition
  • Climagest™. Contains other elements than Эстрадиол in its composition
  • Climara
  • Climen™. Contains other elements than Эстрадиол in its composition
  • Clinorette™. Contains other elements than Эстрадиол in its composition
  • Cliovelle™. Contains other elements than Эстрадиол in its composition
  • Clisin™. Contains other elements than Эстрадиол in its composition
  • CombiPatch™. Contains other elements than Эстрадиол in its composition
  • Delestrogen
  • Dermestril
  • Estalis™. Contains other elements than Эстрадиол in its composition
  • Estrace
  • Estraderm
  • Estragest™. Contains other elements than Эстрадиол in its composition
  • Eviana™. Contains other elements than Эстрадиол in its composition
  • Evopad
  • Evorel Conti™. Contains other elements than Эстрадиол in its composition
  • Femilar™. Contains other elements than Эстрадиол in its composition
  • Ginediol™. Contains other elements than Эстрадиол in its composition
  • Kliofem™. Contains other elements than Эстрадиол in its composition
  • Kliogest™. Contains other elements than Эстрадиол in its composition
  • Kliovance™. Contains other elements than Эстрадиол in its composition
  • Meriestra
  • Merigest™. Contains other elements than Эстрадиол in its composition
  • Mesigyna™. Contains other elements than Эстрадиол in its composition
  • Minivelle
  • Nostidyn™. Contains other elements than Эстрадиол in its composition
  • Progynon
  • Progynova
  • Sequidot™. Contains other elements than Эстрадиол in its composition
  • Systen Conti™. Contains other elements than Эстрадиол in its composition
  • Systen Sequi™. Contains other elements than Эстрадиол in its composition
  • Trisekvens™. Contains other elements than Эстрадиол in its composition
  • Vagifem
  • Valergen
  • Vivelle

Pharmacokinetics

Variable Value Unit
Bioavailability Oral: 5 %
Molecular weight 272 daltons
Protein Binding 98 %
Tmax 1 - 4 hours
T1/2 20 - 26 hours
M/P ratio 0,1 -

References

  1. Pinheiro E, Bogen DL, Hoxha D, Wisner KL. Transdermal estradiol treatment during breastfeeding: maternal and infant serum concentrations. Arch Womens Ment Health. 2015 Abstract Full text (link to original source) Full text (in our servers)
  2. Jordan HL, Bruinsma FJ, Thomson RJ, Amir LH, Werther GA, Venn AJ. Adolescent exposure to high-dose estrogen and subsequent effects on lactation. Reprod Toxicol. 2007 Abstract
  3. Perheentupa A, Ruokonen A, Tapanainen JS. Transdermal estradiol treatment suppresses serum gonadotropins during lactation without transfer into breast milk. Fertil Steril. 2004 Abstract
  4. Gjerdingen D. The effectiveness of various postpartum depression treatments and the impact of antidepressant drugs on nursing infants. J Am Board Fam Pract. 2003 Abstract Full text (link to original source) Full text (in our servers)
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Perheentupa A, Critchley HO, Illingworth PJ, McNeilly AS. Enhanced sensitivity to steroid-negative feedback during breast-feeding: low-dose estradiol (transdermal estradiol supplementation) suppresses gonadotropins and ovarian activity assessed by inhibin B. J Clin Endocrinol Metab. 2000 Abstract Full text (link to original source)
  7. Ball DE, Morrison P. Oestrogen transdermal patches for post partum depression in lactating mothers--a case report. Cent Afr J Med. 1999 Abstract
  8. Illingworth PJ, Seaton JE, McKinlay C, Reid-Thomas V, McNeilly AS. Low dose transdermal oestradiol suppresses gonadotrophin secretion in breast-feeding women. Hum Reprod. 1995 Abstract
  9. Baker VL. Alternatives to oral estrogen replacement. Transdermal patches, percutaneous gels, vaginal creams and rings, implants, other methods of delivery. Obstet Gynecol Clin North Am. 1994 Abstract
  10. Kuhnz W, Gansau C, Mahler M. Pharmacokinetics of estradiol, free and total estrone, in young women following single intravenous and oral administration of 17 beta-estradiol. Arzneimittelforschung. 1993 Abstract
  11. McGarrigle HH, Lachelin GC. Oestrone, oestradiol and oestriol glucosiduronates and sulphates in human puerperal plasma and milk. J Steroid Biochem. 1983 Abstract
  12. Nilsson S, Nygren KG, Johansson ED. Transfer of estradiol to human milk. Am J Obstet Gynecol. 1978 Abstract
  13. Koetsawang S, Bhiraleus P, Chiemprajert T. Effects of oral contraceptives on lactation. Fertil Steril. 1972 Abstract
  14. Kamal I, Hefnawi F, Ghoneim M, Abdallah M, Abdel Razek S. Clinical, biochemical, and experimental studies on lactation. V. Clinical effects of steroids on the initiation of lactation. Am J Obstet Gynecol. 1970 Abstract

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