Last update: July 15, 2017

Dihydrocodeine

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Used for pain and cough relief. As analgesic it is not more effective than Ibuprofen. The enzyme cytochrome P450-CYP2D6 catalyzes its metabolization into dehydromorphine.

On date of latest update relevant data concerning breastfeeding were not found.

Product with similar characteristics than Codeine but with lower oral bioavailability which would be advantageous for breastfed infants. Codeine is excreted into breast milk in non-significant amount, however, serious health problems have appeared among off-spring of mothers who are rapid metabolizers from Codeine to Morphine.

Discontinue if excessive sedation appears in mother or infant, and, do not administer if such a background in mother or family is present, as there are between 1% and 29% of people who are rapid metabolizers from codeine to morphine with an excess of the gene linked to enzyme P450-CYP2D6.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dihydrocodeine in other languages or writings:

Groups

Dihydrocodeine belongs to these groups or families:

Tradenames

Main tradenames from several countries containing Dihydrocodeine in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 20 %
Molecular weight 452 daltons
Tmax 1,2 - 1,8 hours
T1/2 3,5 - 5 hours

References

  1. Paret N, Gouraud A, Bernard N, Bruel M, Cottin J, Descotes J, Vial T. Long-term follow-up of infants exposed to levetiracetam during breastfeeding: Comparison to a control group. (The 2nd International OTIS-ENTIS Conference at The Hospital for Sick Children, Toronto, Canada) Birth Defects Res A Clin Mol Teratol. 2014;100:537-8. Abstract 38. DOI: doi:10.1002/bdra.23258 2014
  2. Edwards JE, McQuay HJ, Moore RA. Single dose dihydrocodeine for acute postoperative pain. Cochrane Database Syst Rev. 2000 Abstract
  3. Rowell FJ, Seymour RA, Rawlins MD. Pharmacokinetics of intravenous and oral dihydrocodeine and its acid metabolites. Eur J Clin Pharmacol. 1983 Abstract

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