Last update: Dec. 8, 2017

Dapagliflozin

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding several T½.
Read the Comment.

Dapagliflozin is a selective and reversible inhibitor of the sodium and glucose co-transporter 2 (SGLT2). It acts by reducing the renal reabsorption of glucose and increasing its elimination via urine (Kasichayanula 2014, Plosker 2014).
Administered orally once a day.

Low risk of hypoglycemia in monotherapy, which increases when it is associated with other hypoglycaemic agents (EMA 2017, Plosker 2014).

Since the last update, we have not found published data on its excretion in breast milk.

Its high percentage of protein binding (EMA 2017) makes its transfer to milk in significant quantities unlikely, but the low molecular weight and its elimination half-life greater than 12 hours could facilitate a possible transfer.

Until there is more published data on this drug in relation to breastfeeding, safer known alternatives may be preferable, especially during the neonatal period and in case of prematurity.

Diet, exercise and breastfeeding improve blood glucose levels.


See below the information of this related product:

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Dapagliflozin is also known as


Dapagliflozin in other languages or writings:

Tradenames

Main tradenames from several countries containing Dapagliflozin in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability 78 %
Molecular weight 409 daltons
Protein Binding 91 %
VD 1,7 l/Kg
Tmax 1 - 2 hours
T1/2 12,9 - 13,8 hours

References

  1. EMA. Dapagliflozina. Ficha técnica. 2017 Full text (in our servers)
  2. EMA. Dapagliflozin. Drug Summary. 2017 Full text (in our servers)
  3. Plosker GL. Dapagliflozin: a review of its use in patients with type 2 diabetes. Drugs. 2014 Abstract
  4. Kasichayanula S, Liu X, Lacreta F, Griffen SC, Boulton DW. Clinical pharmacokinetics and pharmacodynamics of dapagliflozin, a selective inhibitor of sodium-glucose co-transporter type 2. Clin Pharmacokinet. 2014 Abstract

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