Last update: March 27, 2015

Clebopride

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Benzamide derivative agent which is similar to Metoclopramide but with higher extrapyramidal side-effects and poorly known pharmacokinetics.

At latest update, relevant published data on excretion into breast milk were not found.

As with Metoclopramide it produces increased secretion of Prolactin.

Until more data on this medication is available, safer alternative drugs are preferred, especially in such critical age periods.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Clebopride belongs to this group or family:

Tradenames

Main tradenames from several countries containing Clebopride in its composition:

Pharmacokinetics

Variable Value Unit
Molecular weight 374 daltons
Tmax 1 - 2 hours

References

  1. AEMPS. Cleboprida. Ficha técnica. 2014 Full text (in our servers)
  2. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. Síndrome extrapiramidal por cleboprida. \ [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999 Abstract Full text (link to original source) Full text (in our servers)
  3. Serrano Serrano ME, Alvarez Frejo M, Tabernero García J, Martín Martín S. [An extrapyramidal syndrome due to clebopride]. Aten Primaria. 1999 Abstract
  4. Cuena Boy R, Maciá Martínez MA. Toxicidad extrapiramidal a metoclopramida y a cleboprida: estudio de las notificaciones voluntarias de reacciones adversas al Sistema Español de Farmacovigilancia. \ [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998 Abstract Full text (link to original source) Full text (in our servers)
  5. Cuena Boy R, Maciá Martínez MA. [Extrapyramidal toxicity caused by metoclopramide and clebopride: study of voluntary notifications of adverse effects to the Spanish Drug Surveillance System]. Aten Primaria. 1998 Abstract
  6. Jiménez-Jiménez FJ, Ortí-Pareja M, Ayuso-Peralta L, Gasalla T, Cabrera-Valdivia F, Vaquero A, Tejeiro J, García-Albea E. Drug-induced parkinsonism in a movement disorders unit: A four-year survey. Parkinsonism Relat Disord. 1996 Abstract
  7. Perez-Lopez FR, Legido A, Sisskin M, Abos MD. Stimulatory effect of clebopride on human prolactin secretion. Fertil Steril. 1980 Abstract

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