Last update: July 1, 2015

Celecoxib

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Indicated for treatment of Arthritis, Arthrosis and Gout. Acts by blocking cyclooxygenase enzyme (COX-2)

The amount of drug excreted into breast milk is so low that even trace amounts have not been found in blood sera of breastfed infant from treated mothers.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Celecoxib in other languages or writings:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 99 %
Molecular weight 381 daltons
Protein Binding 97 %
VD 5,7 l/Kg
Tmax 3 hours
T1/2 11 hours
M/P ratio 0,3 -
Theoretical Dose 0,01 mg/Kg/d
Relative Dose 0,3 %

References

  1. Reece-Stremtan Sarah, Campos Matilde, Kokajko Lauren, and The Academy of Breastfeeding Medicine. Breastfeeding Medicine. ABM Clinical Protocol #15: Analgesia and Anesthesia for the Breastfeeding Mother, Revised 2017. Breastfeeding Medicine. 2017 Full text (link to original source) Full text (in our servers)
  2. Noviani M, Wasserman S, Clowse ME. Breastfeeding in mothers with systemic lupus erythematosus. Lupus. 2016 Aug;25(9):973-9. Abstract
  3. Götestam Skorpen C, Hoeltzenbein M, Tincani A, Fischer-Betz R, Elefant E, Chambers C, da Silva J, Nelson-Piercy C, Cetin I, Costedoat-Chalumeau N, Dolhain R, Förger F, Khamashta M, Ruiz-Irastorza G, Zink A, Vencovsky J, Cutolo M, Caeyers N, Zumbühl C, Østensen M. The EULAR points to consider for use of antirheumatic drugs before pregnancy, and during pregnancy and lactation. Ann Rheum Dis. 2016 May;75(5):795-810. Abstract Full text (link to original source) Full text (in our servers)
  4. Matsota P, Nakou M, Kalimeris K, Batistaki C, Pandazi A, Kostopanagiotou G. A single dose of celecoxib 200 mg improves postoperative analgesia provided via patient-controlled epidural technique after caesarean section. Arch Med Sci. 2013 Abstract Full text (link to original source) Full text (in our servers)
  5. Sachs HC; Committee On Drugs. The transfer of drugs and therapeutics into human breast milk: an update on selected topics. Pediatrics. 2013 Sep;132(3):e796-809. Abstract Full text (link to original source) Full text (in our servers)
  6. Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: \Transfer of celecoxib into human milk\. J Hum Lact. 2007 Abstract
  7. Ruhlen RL, Chen YC, Rottinghaus GE, Sauter ER. RE: "Transfer of celecoxib into human milk". J Hum Lact. 2007 Abstract
  8. Østensen M, Motta M. Therapy insight: the use of antirheumatic drugs during nursing. Nat Clin Pract Rheumatol. 2007 Abstract
  9. Gardiner SJ, Doogue MP, Zhang M, Begg EJ. Quantification of infant exposure to celecoxib through breast milk. Br J Clin Pharmacol. 2006 Abstract Full text (link to original source) Full text (in our servers)
  10. Hale TW, McDonald R, Boger J. Transfer of celecoxib into human milk. J Hum Lact. 2004 Abstract
  11. Burdan F, Korobowicz A. [Coxibs: highly selective cyclooxygenase-2 inhibitors. Part II. Side effects]. Pol Merkur Lekarski. 2003 Abstract
  12. Knoppert DC, Stempak D, Baruchel S, Koren G. Celecoxib in human milk: a case report. Pharmacotherapy. 2003 Abstract

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