Last update: Oct. 15, 2016

Cefpirome Sulfate

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Fourth-generation cephalosporins for injection or parenteral administration.

At latest update no published data on excretion into breast milk were found.

Most cephalosporins are excreted into milk in insignificant amounts from a therapeutic point of view without reported complications in infants.

Cephalosporins are widely used in the Pediatric practice with a good tolerance, even in the neonatal period, so it is very unlikely that in small amounts through milk would be a cause of problems in the infant.

Be aware of the possibility of false negative results of cultures in febrile infants whose mothers are taking antibiotics as well as the possibility of gastroenteritis (Ito 1993) by altering the intestinal flora.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Cefpirome Sulfate in other languages or writings:

Group

Cefpirome Sulfate belongs to this group or family:

Tradenames

Main tradenames from several countries containing Cefpirome Sulfate in its composition:

Pharmacokinetics

Variable Value Unit
Bioavailability Baja - Poor %
Molecular weight 613 daltons
Protein Binding 10 %
VD 0,3 l/Kg
Tmax 1,5 hours
T1/2 2,3 hours

References

  1. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract
  2. Strenkoski LC, Nix DE. Cefpirome clinical pharmacokinetics. Clin Pharmacokinet. 1993 Abstract
  3. Kavi J, Andrews JM, Ashby JP, Hillman G, Wise R. Pharmacokinetics and tissue penetration of cefpirome, a new cephalosporin. J Antimicrob Chemother. 1988 Abstract

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