Last update: June 10, 2018

C14 H18 N2 O

Very High Risk for breastfeeding


Very unsafe. Contraindicated.
Use of an alternative or cessation of breastfeeding.

An analgesic derived from pyrazolone, inhibitor of prostaglandin synthesis by inhibiting cyclooxygenase.
Administered orally and rectally.

Since the last update date we have not found published data on its excretion in breastmilk.

Severe hemolytic anemia has been reported in a newborn whose mother was taking it (Frei 1985).

Since 1989, it has been withdrawn from sale in many countries for having caused medullary aplasia, Lyell's syndrome and other serious side effects (Onakpoya 2018).

It is marketed in multiple preparations that combine caffeine, codeine, atropine and anti-inflammatory drugs. In general, drug combinations are not recommended and even less so during breastfeeding.

Known alternatives which are safer during breastfeeding are preferred, especially during the neonatal period and in the case of prematurity.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C14 H18 N2 O is Propyphenazone in Molecular formula.

Is written in other languages:

C14 H18 N2 O is also known as

Group

C14 H18 N2 O belongs to this group or family:

Tradenames

Main tradenames from several countries containing C14 H18 N2 O in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 90 %
Molecular weight 230 daltons
Protein Binding 10 - 20 %
VD 1,3 l/Kg
Tmax 1 - 3 hours
T1/2 1 - 1,5 hours

References

  1. Onakpoya IJ, Heneghan CJ, Aronson JK. Post-marketing withdrawal of analgesic medications because of adverse drug reactions: a systematic review. Expert Opin Drug Saf. 2018 Abstract
  2. AEMPS. Saridon. Ficha técnica. 2015 Full text (in our servers)
  3. Frei H, Bühlmann U, Rudin O. [Toxic hemolytic anemia in the newborn infant following ingestion of a phenazone derivative (Cibalgin) via breast milk]. Z Geburtshilfe Perinatol. 1985 Jan-Feb;189(1):11-2. German. Abstract

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