Last update: June 10, 2018

C14 H16 N4

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

This is a immune-response modifier, used in the local treatment of genital and perianal warts, cutaneous basal cell tumors and actinic keratosis.
Administered topically, once a day or every two days for several weeks, according to pathology.

Since the last update we have not found any published data on its excretion in breastmilk.

The cutaneous absorption to the patient's blood is extremely low: 0.6% with a Cmax of 0.32 to 1.6 ng/mL (EMA 2016, Wu 2012, Kulp 2010, Harrison 2004, FDA 2004), which makes it very unlikely that there is transfer in significant amounts to breastmilk.

As with any product applied to the skin, it is prudent to avoid its use in areas near the breast and nipple so that there is no risk of swallowing by the infant.

Alternatives

We do not have alternatives for C14 H16 N4 since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C14 H16 N4 is Imiquimod in Molecular formula.

Is written in other languages:

Group

C14 H16 N4 belongs to this group or family:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. derm: 0,6 %
Molecular weight 240 daltons
T1/2 24 hours

References

  1. EMA. Imiquimod (Aldara). Ficha técnica. 2016 Full text (in our servers)
  2. EMA. Imiquimod (Aldara). Drug Summary. 2016 Full text (in our servers)
  3. Wu J, Feldman R, Barry GT, Kulp J, Adams MP, Levy S. Pharmacokinetics of daily self-application of imiquimod 3.75% cream in adult patients with external anogenital warts. J Clin Pharmacol. 2012 Abstract
  4. Kulp J, Levy S, Fein MC, Adams M, Furst J, Meng TC. Pharmacokinetics of imiquimod 3.75% cream applied daily for 3 weeks to actinic keratoses on the face and/or balding scalp. Arch Dermatol Res. 2010 Abstract
  5. Harrison LI, Skinner SL, Marbury TC, Owens ML, Kurup S, McKane S, Greene RJ. Pharmacokinetics and safety of imiquimod 5% cream in the treatment of actinic keratoses of the face, scalp, or hands and arms. Arch Dermatol Res. 2004 Abstract
  6. FDA. Imiquimod (Aldara). Drug Summary. 2004 Full text (in our servers)

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