Last update: May 21, 2020

C03BA11

Low Risk for breastfeeding


Moderately safe. Probably compatible.
Mild risk possible. Follow up recommended.
Read the Comment.

Thiazide-like diuretic.
indicated in the treatment of hypertension and for oedema associated with heart failure
Oral administration once a day.

Since the last update we have not found any published data on its excretion in breast milk.

Long-term treatment with diuretic drugs (particularly those Thiazides with long lasting effect and loop-acting drugs) may inhibit lactation, but despite some older studies, there is no scientific evidence that diuretics reduce breast milk production (Rowe 2013).
Use a lower dose as possible, especially during the first postnatal month.

Expert authors consider the use of this medication to be probably compatible during breastfeeding (Hale 2019, Briggs 2017).

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

C03BA11 is Indapamide in ATC Code/s.

Is written in other languages:

Group

C03BA11 belongs to this group or family:

Tradenames

Main tradenames from several countries containing C03BA11 in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 93 %
Molecular weight 366 daltons
Protein Binding 71 - 79 %
pKa 8,85 -
Tmax 1 - 2 hours
T1/2 18 (14 - 24) hours

References

  1. Hale TW. Hale's Medications & Mothers' Milk. Springer Publishing Company. 2019
  2. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  3. Malachias MV, Figueiredo CE, Sass N, Antonello IC, Torloni MR, Bortolotto MRF L. 7th Brazilian Guideline of Arterial Hypertension: Chapter 9 - Arterial Hypertension in pregnancy Arq Bras Cardiol. 2016 Abstract Full text (link to original source) Full text (in our servers)
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. Normon. Indapamida. Ficha técnica. 2011 Full text (in our servers)
  6. Sanis. Indapamide. Drug Summary. 2011 Full text (in our servers)

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