Last update: May 13, 2019

Chlorothiazide

Very Low Risk for breastfeeding


Safe. Compatible.
Not risky for breastfeeding or infant.

Thiazide diuretic. Indicated in the treatment of hypertension and edema secondary to heart failure.
Oral administration once-twice a day.

Milk levels of a mother who took 500 mg of chlorothiazide were undetectable or very low, <1 mg / L (Werthmann 1972).

Despite some older studies, there is no scientific evidence that diuretics reduce breast milk production (Anderson 2018, Rowe 2013).

Several medical societies, experts and expert consensus, consider the use of this medication safe or probably safe during breastfeeding (Briggs 2017, Hale 2017 p190).
American Academy of Pediatrics: Maternal Medication Usually Compatible With Breastfeeding (AAP 2001).

Long-term treatment with diuretic drugs may compromise the state of hydration of the nursing mother. Must make an adjustment (decrease) of the dose based on the estimated milk production and monitor milk production.


See below the information of this related product:

Alternatives

We do not have alternatives for Chlorothiazide since it is relatively safe.

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Other names

Chlorothiazide is also known as


Chlorothiazide in other languages or writings:

Group

Chlorothiazide belongs to this group or family:

Tradenames

Main tradenames from several countries containing Chlorothiazide in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. 20 %
Molecular weight 296 daltons
Protein Binding 95 %
VD 0,3 l/Kg
pKa 9,1 -
Tmax 1 hours
T1/2 0,75 - 2 hours
M/P ratio 0,25 -
Theoretical Dose < 0,15 mg/Kg/d
Relative Dose < 1,8 %
Relat.Ped.Dose < 1,5 %

References

  1. Anderson PO. Treating Hypertension During Breastfeeding. Breastfeed Med. 2018 Abstract
  2. Hale TW, Rowe HE. Medications & Mothers' Milk. A Manual of Lactation Pharmacology. Springer Publishing Company. 2017
  3. Briggs GG, Freeman RK, Towers CV, Forinash AB. Drugs in Pregnancy and Lactation: A Reference Guide to Fetal and Neonatal Risk. Wolters Kluwer Health. 11th edition (acces on line) 2017
  4. Rowe H, Baker T, Hale TW. Maternal medication, drug use, and breastfeeding. Pediatr Clin North Am. 2013 Feb;60(1):275-94. Abstract
  5. AAP - American Academy of Pediatrics Committee on Drugs. Transfer of drugs and other chemicals into human milk. Pediatrics. 2001 Sep;108(3):776-89. Abstract Full text (link to original source) Full text (in our servers)
  6. Werthmann MW Jr, Krees SV. Excretion of chlorothiazide in human breast milk. J Pediatr. 1972 Abstract

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