Last update: June 30, 2015

Azelastine

Low Risk probable for breastfeeding


Moderately safe.
Mild risk possible. Follow up recommended.
Read the Comment.

Second generation anti-histaminic drug with low sedative effect. Used for ophthalmic and nasal topical administration.

On last update no relevant published data related to breastfeeding were found.

A small dose together with a low plama level of most nasal and ophthalmologic compounds make that a significant excretion into breast milk would be unlikely.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

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Other names

Azelastine in other languages or writings:

Groups

Azelastine belongs to these groups or families:

Pharmacokinetics

Variable Value Unit
Bioavailability 40 %
Molecular weight 418 daltons
Protein Binding 80 - 90 %
VD 15 l/Kg
Tmax 2 - 5 hours
T1/2 22 - 35 hours

References

  1. So M, Bozzo P, Inoue M, Einarson A. Safety of antihistamines during pregnancy and lactation. Can Fam Physician. 2010 May;56(5):427-9. Abstract Full text (link to original source) Full text (in our servers)
  2. Ito S, Blajchman A, Stephenson M, Eliopoulos C, Koren G. Prospective follow-up of adverse reactions in breast-fed infants exposed to maternal medication. Am J Obstet Gynecol. 1993 May;168(5):1393-9. Abstract

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