Last update: Oct. 27, 2014

Argatroban

High Risk for breastfeeding


Poorly safe. Evaluate carefully.
Use safer alternative or interrupt breastfeeding 3 to 7 T ½ (elimination half-lives).
Read the Comment.

On latest update relevant data on breastfeeding was not found. Absorption by the intestine is unknown.

Although a better known and safer alternative is preferred, because of short half-life a delay of 3-4 hours period after last dose would permit to minimize any risk.

Alternatives

Suggestions made at e-lactancia are done by APILAM´s pediatricians and pharmacists, and are based on updated scientific publications.
It is not intended to replace the relationship you have with your doctor but to compound it.

Jose Maria Paricio, Founder & President of APILAM/e-Lactancia

Your contribution is essential for this service to continue to exist. We need the generosity of people like you who believe in the benefits of breastfeeding.

Thank you for helping to protect and promote breastfeeding.

José María Paricio, founder of e-lactancia.

Group

Argatroban belongs to this group or family:

Tradenames

Main tradenames from several countries containing Argatroban in its composition:

Pharmacokinetics

Variable Value Unit
Oral Bioavail. ? %
Molecular weight 509 daltons
Protein Binding 54 %
VD 0,2 l/Kg
Tmax 1 - 3 hours
T1/2 0,6 - 0,9 hours

References

  1. [No authors listed] Argatroban: for a few selected patients. Prescrire Int. 2013 Abstract
  2. Yurdakök M. Fetal and neonatal effects of anticoagulants used in pregnancy: a review. Turk J Pediatr. 2012 Abstract Full text (link to original source) Full text (in our servers)
  3. Walenga JM. An overview of the direct thrombin inhibitor argatroban. Pathophysiol Haemost Thromb. 2002 Abstract Full text (in our servers)

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